Analysis and modeling of brain's dynamics of sleep stage transitions

我们研究了运动后增加睡眠压力对健康受试者第2阶段睡眠和脑电图动态方面的影响，以揭示调节睡眠阶段转换的开关的特征。 所有的受试者都没有睡眠障碍。 运动后，受试者从第1阶段过渡到第2阶段的概率显著（p < 0.05）高于基线，而从第1阶段过渡到清醒的概率显著（p < 0.05）低于基线。 对于过渡到其他睡眠阶段之前的阶段2期间的脑电图，与过渡到其他睡眠阶段相比，分别在过渡到慢波睡眠（SWS）和清醒或阶段1之前，睡眠纺锤波和K复合波的数量显著增加（p < 0.05）。 这些结果表明，动态睡眠形态可以使用阶段2-唤醒/阶段1开关、阶段2-REM开关和阶段2-SWS开关的数学模型来模拟。

We investigated the effects of an increase sleep pressure after exercise on dynamic aspects of sleep and electroencephalogram during Stage2 in healthy subjects to reveal the characteristics of switches which regulate sleep stage transitions. All the subjects were negative for sleep disorders. After exercise, the subjects showed a significantly (p < 0.05) greater probability of transition from Stage1 to Stage2 and a significantly (p < 0.05) lower rate of transition from Stage1 to wake than baseline. For electroencephalogram during Stage2 just before transitions to other sleep stages, the number of sleep spindles and K-complexes significantly (p < 0.05) increased before transitions to slow wave sleep (SWS) and wake or Stage1 compared to transitions to other sleep stages, respectively. These results suggest that dynamic sleep morphology might be simulated using mathematical models of a Stage2-wake/Stage1 switch, a Stage2-REM switch, and a Stage2-SWS switch.