Relationship between lipid droplets and peroxisomes through the mitochondria-associated ER membrane

我们研究了内质网的一个亚域--线粒体相关膜(MAM)是否参与了脂滴的形成和过氧化物体的生物发生。脂滴的形成被MAM组织蛋白的敲除所抑制，如Synaxin17。Rab32也可能有助于脂滴的形成。在某种细胞类型中，Sec16B的缺失导致脂滴的形成和过氧化体的延长，而在另一种类型的细胞中，Sec16B的缺失抑制了脂滴的形成和过氧化体的缩短。提示MAM在脂滴形成过程中起着重要作用，脂滴的形成与过氧化物体的生物发生有密切关系。

We examined whether the MAM (mitochondria-associated membrane), a subdomain of the endoplasmic reticulum, participates in lipid droplet formation and peroxisome biogenesis. Lipid droplet formation was suppressed by knockdown of MAM-organizing proteins, such as syntaxin17. Rab32 may also contribute to lipid droplet formation. Depletion of Sec16B caused lipid droplet formation and elongation of peroxisomes in a certain cell type, but suppressed lipid droplet formation and shortened peroxisomes in another type of cells. The data suggest that the MAM has an important role in lipid droplet formation, and that there is an intimate relation between lipid droplet formation and peroxisome biogenesis.