Discovery of new function of organophosphorus compounds and their applications to catalytic asymmetric synthesis

我们专注于磷化物化合物，如磺胺作为阴离子配体的前体，这到目前为止还没有报道过。我们首先考察了苯基膦的反应。但没有得到磷化物。然后，我们检查了实验，以证实使用二苯基膦和对甲苯磺酰氯的已知程序。令人惊讶的是，我们得到了甲苯硫氧基二苯基膦氧化物，而不是预期的磷化物。在此基础上，我们重新考察了苯基膦与对甲苯磺酰氯的反应，得到了苯硫膦苯硫酯。有趣的是，该反应是硫磷歧化反应的全新反应。接下来，我们重点研究了苯基膦与酰化剂的反应。当磷化硼取代磷化氢时，所需的磷化物被分离为硼烷络合物。现在我们正在检查从产品中去除硼烷的情况。

We focused on phosphide compounds like a sulfonamide as a precursor of an anionic ligand, which have never been reported to date. We first examined the reaction of phenyl phosphine. But no phosphide was obtained. Then, we examined the experiments to corroborate the known procedure using diphenylphosphine and tosyl chloride. Surprisingly, we obtained tolylthiooxydiphenylphosphine oxide instead of the expected phosphide. Based on the results, we re-examined the reaction of phenylphosphine with tosyl chloride, which afforded phenylthiophosphonic acid phenyl thioester. Interestingly, this reaction is a completely new reaction through disproportionation reaction between sulfur and phosphorus. Next, we focused on the reaction of phenyl phosphine with acylating agents. When phosphine borane instead of phosphine, the desired phosphide was isolated as a borane complex. Now we are examining the removal of the borane from the product.