课题基金 / 基金详情

nalysis of non-coding RNAs transcribed from ultraconserved regions in digestive tract cancer and its diagnostic and therapeutic application

nalysis of non-coding RNAs transcribed from ultraconserved regions in digestive tract cancer and its diagnostic and therapeutic application
消化道癌超保守区转录非编码RNA分析及其诊断和治疗应用
批准号：
24659163
负责人：
YASUI Wataru
金额：
$2.5万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659163/
关键词：
ncRNA超保存領域（T-UCR)消化管癌診断・治療展開発現制御メチル化非翻訳RNA超保存領域（T-UCR）

项目摘要

项目成果

YASUI Wataru的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Transcribed ultraconserved region (T-UCR) transcripts are a novel class of long non-coding RNAs transcribed from ultraconserved regions (UCRs). The expression analysis of T-UCR in digestive tract cancers demonstrated that, in gastric cancer, most of T-UCRs including UCR118+A and 158+A were down-regulated by methylation, whereas UCR416+A and 420+A were overexpressed. Down-regulation of miR-148 and miR-143/-145 participated in cancer invasion and morphogenesis with interaction with stromal cells and served as prognostic factor of gastric cancer patients.
期刊论文(62)
专著(0)
科研奖励(0)
会议论文
Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-a secretion in gastric cancer
由 SEC11A 编码的信号肽酶复合物 18 通过 TGF-a 分泌促进胃癌进展
DOI： --
发表时间：
期刊： Oncogene
影响因子： 8
作者： [Oue N, Naito Y, Hayashi T, Takigahira M, Kawano-Nagatsuma A, Sentani K, Sakamoto N, Zarni Oo H, Uraoka N, Yanagihara K, Ochiai A, Sasaki H, Yasi W]
通讯作者： Yasi W
Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
DOI： 10.1002/ijc.27735
发表时间： 2013-02-15
期刊： INTERNATIONAL JOURNAL OF CANCER
影响因子： 6.4
作者： [Shinagawa, Kei, Kitadai, Yasuhiko, Chayama, Kazuaki]
通讯作者： Chayama, Kazuaki
Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis
DOI： 10.1093/carcin/bgs121
发表时间： 2012-05-01
期刊： CARCINOGENESIS
影响因子： 4.7
作者： [Sentani, Kazuhiro, Oue, Naohide, Yasui, Wataru]
通讯作者： Yasui, Wataru
Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice
Claudin-18 缺乏会导致小鼠细胞旁 H 渗漏、白细胞介素 1β 上调和萎缩性胃炎
DOI： --
发表时间： 2011
期刊： Gastroenterology
影响因子： 29.4
作者： [Travis WD, et al, Hayashi D]
通讯作者： Hayashi D
共 42 条
    Protein processing system-regulating microRNA in gastrointestinal carcinogenesis and its clinical application
    • 批准号：
      22659074
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.02万
    • 财政年份：
      2010
    • 负责人：
      YASUI Wataru
    • 依托单位：
      Hiroshima University
    Analysis of genes encoding secretory and membrane protein by CAST method and microRNA regulation in esophago-gastric cancer and its clinical application
    • 批准号：
      21390105
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.81万
    • 财政年份：
      2009
    • 负责人：
      YASUI Wataru
    • 依托单位：
      Hiroshima University
    Functional analysis of gastric cancer-specific genes identified by SAGE data and its clinical implication
    • 批准号：
      17390104
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.28万
    • 财政年份：
      2005
    • 负责人：
      YASUI Wataru
    • 依托单位：
      Hiroshima University
    Molecular characterization of gastrointestinal cancer through serial analysis of gene expression and GICHIP and its diagnostic implication
    • 批准号：
      15390116
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.79万
    • 财政年份：
      2003
    • 负责人：
      YASUI Wataru
    • 依托单位：
      HIROSHIMA UNIVERSITY
    海外基金