The analysis of the macular blood flow in patients with retinitis pigmentosa

本文应用激光散斑血流图(LSFG)对视网膜色素变性(RP)患者的黄斑血流及其与视功能的相关性进行了研究。我们的数据显示，与对照组相比，RP患者的黄斑血流量减少了约60%。此外，黄斑血流量的减少与RP患者黄斑视觉敏感度的降低有关。我们证明了局部应用乌索前列酮异丙醇可能对RP患者具有治疗效果，如改善黄斑敏感度。令人惊讶的是，黄斑敏感度不仅在接受治疗的眼睛中保持，而且在对侧眼中也保持不变。RP患者的黄斑血流变化率在治疗眼和对侧眼均显著增加。这些结果表明，局部应用乌索前列酮可能具有改善黄斑血流的治疗效果。

In the present study, we investigated the macular blood flow using laser speckle flowgraphy (LSFG) in patients with retinitis pigmentosa (RP) and its correlation with visual function. Our data showed that macular blood flow was decreased to approximately 60% in RP patients compared with control subjects. Moreover, the decreased macular blood flow was associated with the reduction of macular visual sensitivity in RP patients.We demonstrated topical unoprostone isopropyl might have a therapeutic efficacy, such as improvements of the macular sensitivity, in patients with RP. Surprisingly, the macular sensitivity was maintained not only in the treated eyes, but also in the fellow eyes. The change ratios of macular blood flow obtained from RP patient were significantly increased in both the treated and the fellow eyes. These results demonstrate that topical unoprostone might have a therapeutic efficacy as a consequence of the macular blood flow improvement.