Experimental study towards the development of lymphatic drug delivery system for the treatment of cervical lymph node metastasis

本研究通过建立小鼠颈淋巴结转移模型，探讨微创淋巴内化疗治疗颈淋巴结转移的可能性。这项研究表明，选择性淋巴内给药是可行的。此外，经淋巴管将纳米微泡和抗癌剂同时注入转移淋巴结后，用超声波照射可增强抗癌剂对靶淋巴结细胞的有效诱导作用。

The present study was performed to examine the possibility of intra-lymphatic chemotherapy with minimally invasiveness for cervical lymph node metastasis by using the lymph node metastasis mouse model showing lymphadenopathy. This study revealed that selective intra-lymphatic administration of anticancer agent is available. Moreover, it became clear that irradiation of ultrasonic waves after the simultaneous administration of nano-microbubbles and anticancer agent into the metastatic lymph node via lymphatic vessel enhanced effective induction of anticancer agent into the cells of the targeted lymph node.