Dynamic imaging and modelling of the regulation of T cell - pathogen equilibration during chronic infection (B31*)

本项目研究慢性感染过程中免疫反应和持续病原体之间平衡的分子信号和细胞动力学。使用动态体内成像和利什曼原虫感染的数学建模相结合，B31N将建立效应和调节T细胞功能对病原体生理学的影响。此外，T细胞的活化将在其体内细胞相互作用的背景下进行评估。获得的实验数据将用于通知基于代理和微分方程模型，以研究免疫细胞和病原体群体的进化以及T细胞激活信号的动态。

This project investigates the molecular signaling and cellular dynamics underlying the equilibration between the immune response and persisting pathogens in the course of a chronic infection. Using a combination of dynamic in vivo imaging and mathematical modelling of Leishmania major infection, B31N will establish the impact of effector and regulatory T cell functions on pathogen physiology. Furthermore, the activation of T cells will be assessed in the context of their cellular interactions in vivo. The experimental data obtained will be used to inform agent-based and differential equation models in order to study the evolution of immune cell and pathogen populations as well as the dynamics of T cell activation signaling.