Developmentofcontrol for amyloid toxicity by novel Screening system

淀粉样蛋白纤维通常在生物膜上繁殖以诱导细胞毒性。与此同时，目前还没有阻止上述事件的方法。在这项研究中，我们挑战了利用脂质体控制淀粉样蛋白纤维毒性的发展。研究表明，脂质体文库可提供(1)有利于控制淀粉样蛋白纤维毒性的脂类成分；(2)具有促进纤维形成或解聚抑制作用的LIPOzyme。这些结果暗示了利用脂质体研究淀粉样蛋白纤维解毒过程的可能性。

Amyloid fibrils is generally propagated on biomembranes to induce the cell toxicity. Meanwhile, there is no methodology to stop the aforesaid event. In this study, we challenged the development of toxicity control of amyloid fibrils using liposomes. It has been demonstrated that liposome library could give (i) the adequate liposome with lipid composition advantageous for a control of toxicity of amyloid fibrils and (ii) LIPOzyme with the function to promote the inhibitory of fibril formation or disaggregatiojn of fibrils. Those results have implied a possibility on the development of detoxic process of amyloid fibrils by using liposomes.