Inter-relationship analysis of genetic polymorphism of human bitter-taste receptor TAS2R and hepatic detoxification enzyme GSTs

流行病学研究表明，十字花科植物中的异硫氰酸酯化合物可降低癌症的发病率。 如果通过TAS 2 R（苦味受体）品尝这种苦味化合物，则这种化合物的摄入量可能会因其在进食过程中的苦味过多而减少。 另一种可能性是肝谷胱甘肽S-转移酶（GST）多态性。 后者参与了异硫氰酸酯化合物在肝脏进食后的解毒机制，即，由于GST酶的多态性，如果GST活性低，我们就不能吃十字花科植物。 因此，我们分析了TAS 2 Rs和GSTs多态性在人类志愿者中的关系，并试图阐明十字花科植物可接受性个体差异的机制。 到目前为止，我们发现GST同工酶中的一种可能参与了这种可接受性，这可能与TAS 2 R38对PTC的无味性有关，但还需要进一步的详细研究。

Epidemiological studies have shown that isothiocyanate compounds in the cruciferous plant prevents cancer incidence rate. If the taster of this bitter compounds by TAS2R, bitter taste receptor, the intake of this compound may decrease due to its too much bitterness sensation during eating. Another possibility is hepatic glutathione S-transferase (GST) polymorphism. The latter one is involved in the detoxification mechanism of isothiocyanate compounds after eating in the liver, i.e., we cannot eat cruciferous plants if the GST activity is low due to its enzyme polymorphism. Therefore, we analyzed the relationship of TAS2Rs and GSTs polymorphism in human volunteer, and intended to clarify the mechanism involved in the individual difference of cruciferous plant acceptability. Up to now, we found that one of the GST isozyme may be involved in this acceptability, and this may be associated with the non-taster of PTC by TAS2R38, though further detailed study is necessary.