Innovative Approaches for Defining the Interaction of Insulin like Growth Factor I (IGF I) with the Type 1 IGF Receptor

这项研究将提高我们对胰岛素样生长因子（IGFs）与其主要受体IGF-1 R相互作用的理解。 对这些相互作用的充分理解对于开发用于治疗应用的非肽类IGF拮抗剂是必不可少的。 这些分子可能会导致新的治疗方法，其中IGF系统的失调已涉及包括癌症，糖尿病和动脉粥样硬化的疾病。 由于IGFs是增长的主要决定因素，该项目的成果也可能导致畜牧业生产的改善，对第一产业产生重大利益。 新开发的IGF类似物可有助于生物技术出口。

This study will improve our understanding of the interactions of Insulin-like Growth Factors (IGFs) with their principal receptor, the IGF-1R. A sound understanding of these interactions is essential for the development of non-peptide IGF antagonists designed for therapeutic applications. Such molecules could lead to new therapeutic approaches for diseases in which dysregulation of the IGF system has been implicated including cancer, diabetes and atherosclerosis. Since IGFs are major determinants of growth, the outcomes of this project could also lead to improvements in animal production with major benefit to primary industry. New IGF analogues developed could assist biotechnology exports.