Defining the viral PTMome: Towards the development of novel antiviral approaches

定义病毒 PTMome:致力于开发新型抗病毒方法

基本信息

  • 批准号:
    10261712
  • 负责人:
  • 金额:
    $ 112.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-30 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Over the past several decades, the traditional approach to combating viral infectious diseases has been to target the virus itself, in most cases by either blocking virus-encoded enzymes that are required for viral replication, or by preventing the virus from entering host cells. One of the major caveats of these approaches has been the ability of the virus to readily mutate and thereby become resistant to these classical types of antiviral therapies. In fact, this is a serious problem for the therapy of RNA virus infections, such as HIV or influenza virus, which are known to rapidly mutate and thereby escape antiviral drugs. Additionally, traditional antiviral approaches are designed to target a specific virus, and therefore are ineffective against any new virus that may emerge in the future, and it is impossible to predict what virus will cause the next outbreak or pandemic. Therefore, there is the urgent need to develop new ways for targeting viral pathogens, which will require creative and innovative research. Like human proteins, viral proteins robustly undergo posttranslational modifications (PTMs) for their regulation and proper functioning in the virus life cycle. In most cases, viral PTMs are dynamically regulated by human enzymes, such as kinases/phosphatases, ubiquitin E3 ligases/deubiquitinating enzymes, or acetyl transferases/deacetylases. Thus, cellular enzymes play an important role in controlling the ability of the virus to replicate and to cause disease. This proposal’s overarching goal is to comprehensively map the ‘viral PTMome’ to identify the PTMs that are essential for virus replication and pathogenesis. We will combine proteomics screens and molecular virology approaches including reverse genetics techniques with cutting- edge molecular, biochemical and biophysical studies. This will allow us to identify and characterize viral PTMs and the responsible host modifying enzymes, as well as to determine their roles for effective viral replication and pathogenesis. This powerful approach, combined with collaborative studies to design and test chemical inhibitors to block the enzymes that regulate critical viral PTMs, will not only provide unique mechanistic insight into host control of virus replication but will also lay the groundwork for developing new antivirals for a range of emerging viral infectious diseases.
项目总结

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Michaela Ulrike Gack其他文献

Michaela Ulrike Gack的其他文献

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{{ truncateString('Michaela Ulrike Gack', 18)}}的其他基金

Role of ADAM9 in viral RNA sensing and antiviral innate immunity
ADAM9 在病毒 RNA 传感和抗病毒先天免疫中的作用
  • 批准号:
    10753041
  • 财政年份:
    2023
  • 资助金额:
    $ 112.7万
  • 项目类别:
Defining the viral PTMome: Towards the development of novel antiviral approaches
定义病毒 PTMome:致力于开发新型抗病毒方法
  • 批准号:
    10490866
  • 财政年份:
    2021
  • 资助金额:
    $ 112.7万
  • 项目类别:
Defining the viral PTMome: Towards the development of novel antiviral approaches
定义病毒 PTMome:致力于开发新型抗病毒方法
  • 批准号:
    10662495
  • 财政年份:
    2021
  • 资助金额:
    $ 112.7万
  • 项目类别:
Novel Role for Host Immunostimulatory RNA in Antiviral Immune Defense
宿主免疫刺激 RNA 在抗病毒免疫防御中的新作用
  • 批准号:
    10338487
  • 财政年份:
    2021
  • 资助金额:
    $ 112.7万
  • 项目类别:
Novel Role for Host Immunostimulatory RNA in Antiviral Immune Defense
宿主免疫刺激 RNA 在抗病毒免疫防御中的新作用
  • 批准号:
    10492729
  • 财政年份:
    2021
  • 资助金额:
    $ 112.7万
  • 项目类别:
Novel Role for Host Immunostimulatory RNA in Antiviral Immune Defense
宿主免疫刺激 RNA 在抗病毒免疫防御中的新作用
  • 批准号:
    10676843
  • 财政年份:
    2021
  • 资助金额:
    $ 112.7万
  • 项目类别:
The Role of TRIM23 in Autophagy Mediated Antiviral Defenses
TRIM23 在自噬介导的抗病毒防御中的作用
  • 批准号:
    10394983
  • 财政年份:
    2020
  • 资助金额:
    $ 112.7万
  • 项目类别:
The Role of TRIM23 in Autophagy Mediated Antiviral Defenses
TRIM23 在自噬介导的抗病毒防御中的作用
  • 批准号:
    10623146
  • 财政年份:
    2020
  • 资助金额:
    $ 112.7万
  • 项目类别:
The Role of TRIM23 in Autophagy Mediated Antiviral Defenses
TRIM23 在自噬介导的抗病毒防御中的作用
  • 批准号:
    10353335
  • 财政年份:
    2020
  • 资助金额:
    $ 112.7万
  • 项目类别:
EBV infection control by RNA surveillance
通过 RNA 监测控制 EBV 感染
  • 批准号:
    10283975
  • 财政年份:
    2019
  • 资助金额:
    $ 112.7万
  • 项目类别:

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