Development and systematization of telemetering equipments used for coronary hemodynamic in conscious dogs.

为了对非麻醉、非束缚状态下的犬进行血压、冠状动脉血流、心外膜大冠状动脉直径、左心室直径等的远距离模拟和数字记录，以研究抗心绞痛药物的血流动力学效应，我们研制了微型压力遥测仪、多普勒血流遥测仪和渡越时间维遥测仪，并分别进行了无线接收和解调，应用硝酸甘油5 μ g/kg舌下含服可有效增加左回旋支直径，作用持续5-8 min，并观察了抗心绞痛药物对心外膜大冠状动脉直径、左心室内径、LVP、LVdp/dt、LVEDP、冠状动脉血流量、血压、心率及心电图的影响。而冠状动脉血流量、心率、血压、左室内径、LVEDP和LVdp /dt无明显变化。随着剂量增加至25 μ g/kg，这些效应基本上没有改变。结论：硝酸甘油对心绞痛的主要治疗作用与扩张大冠状动脉有关。

In order to make remote analog and digital recordings of blood pressure, coronary blood flow, diameters of large epicardial coronary artery and of left ventricle and others from unanesthetized and unrestrained dogs for the study on hemodynamic effects of antianginal drugs, we developed a miniature pressure telemeter, blood flow telemeter based on Doppler principle and a transit time dimension telemeter and their radio-receiver and demodulating, signals and deta processing systems.In application, we examined effects of some anti-anginal drugs on diameters of epicardial large coronary artery and left ventricle, LVP, LVdp/dt, LVEDP, coronary blood flow, blood pressure, heart rate and ECG.Sublingual nitroglycerin 5 microgram/kg effectively increased left circumflex coronary diameter, the effect lasted 5-8 minutes. However, coronary blood flow, heart rate, blood pressure, left ventricular diameter, LVEDP and LVdp /dt were not significantly changed. With increasing dose up to 25 microgram/kg, these effects have not changed basically. It is concluded that the prime therapeutic action of nitroglycerin in angina pectoris is related to dilate large coronary arteries.