Development of Ultrasonic Two-dimensional Tissue Characterization System

为了无创评估慢性肝病的病理变化，我们利用改进的常规超声扫描仪从人肝脏获得的超声波形计算肝脏的频率相关衰减系数（FDA）和散射体间距。FDA与肝脏脂肪浸润分级呈正相关。提示可以无创、定量地测量肝脏脂肪变化的严重程度。假设肝组织是半规则排列的超声小散射体的集合，我们可以通过倒谱分析测量散射体之间的空间（SAS）。在这项研究中，从每个患者的SAS分布中得出了两个参数，即模式和峰度。利用模式和峰度可以无创定量评价慢性肝病的病理变化。

In order to evaluate the pathological changes in chronic liver disease non-invasively, we calculated frequency dependent attenuation coefficient (FDA) and space among scatterers of the liver from the ultrasonic waveforms obtained from human livers using the modified conventional ultrasonic scanner.FDA showed positive correlation with the grading of fatty infiltration of the liver. and it is suggested that we could measure the severity of fatty change of the liver non-invasively and quantitatively.Assuming that liver tissue is the collection of semi-regularly arrayed small scatterers of ultrasouncwe could measure the space among scatterers(SAS) by the cepstral analysis. In this study, two parameters, mode and kurtosis, were yielded from the distribution of the SAS for each patient. Using mode and kurtosis, we could evaluate the pathological change of chronic liver disease non-invasively and quantitatively.