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Epithelial transformation by stroma transplant in urogenital organs

泌尿生殖器官基质移植的上皮转化

基本信息

批准号：
16591631
负责人：
HAYASHI Norio
金额：
$ 2.18万
依托单位：
Aichi Cancer Center (Research Institute)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591631/
关键词：
bladder prostate uters storma epithelium mouse nude mouse rat 泌尿生殖洞動物病理学秘尿生殖洞胎児前胃

项目摘要

Squamous hyperplasia of bladder epithelium was induced when stromal tissues of urogenital sinus were transplanted near the bladder epithelium of male mice. In addition, prostate-like glandular structure was sometimes observed in the bladder of the mice. When the section of glandular epithelial cells was stained with anti-prostate specific antibody, positive reaction was observed. These results show that the part of bladder epithelium of in situ induced in urogenital sinus stroma shows morphologically functionally changing in the prostate epithelium. As a similar experiment, it was confirmed that the epithelium of uterus changed to that of vagina, when the stroma of urogenital sinus was transplanted into uterine cavity of female mice before sexual maturation. And, the hyperplasia of the mouse prostate epithelium was able to be induced, when rat urogenital sinus stroma was transplanted in prostate of nude mice. The derivation of the tissues was distinguished by the antibody which peculiarly reacted with rat or mouse.The bladder epithelium showed the hyperplasia, when the stroma of proventriculus was transplanted in the bladder. Furthermore, some of epithelium took the small gland structure that was not proventriculus and was not bladder too. As for this phenomenon, it is supposed that confusion occurred by a lot of information being given bladder epithelium at the same time from transplanted and original bladder stromal tissues. Or it is thought that an abnormal hyperplasia is caused by stimulation for bladder epithelium from stroma of the genetically different organs.

将泌尿生殖窦间质组织移植到雄性小鼠膀胱上皮附近，可诱导膀胱上皮鳞状增生。此外，有时在小鼠膀胱中观察到前列腺样腺结构。腺上皮细胞切片用抗前列腺特异性抗体染色，阳性反应。这些结果表明，原位诱导的膀胱上皮部分在泌尿生殖窦间质中出现了形态功能上的改变。类似实验证实，在性成熟前将泌尿生殖窦间质移植到雌鼠子宫腔内，子宫上皮向阴道上皮转变。将大鼠泌尿生殖窦间质移植到裸鼠前列腺后，可诱导小鼠前列腺上皮增生。该抗体对大鼠或小鼠有特异性反应，从而区分了该组织的来源。前脑室间质移植膀胱后，膀胱上皮增生。部分上皮呈小腺体结构，不属于前室，也不属于膀胱。对于这一现象，可能是由于移植膀胱间质组织和原膀胱间质组织同时给予膀胱上皮大量信息而造成的混淆。或者认为异常增生是由基因不同器官间质对膀胱上皮的刺激引起的。

项目成果

期刊论文数量（56）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen N-butyl-N-nitrosourea.

针对小鼠胸腺白血病抗原 (TL) 的免疫可防止由化学致癌物 N-丁基-N-亚硝基脲诱发的淋巴瘤的发展。

DOI：
发表时间：
2004
期刊：
Cancer Sci 95
影响因子：
0
作者：
Tsujimura;K.;et al.
通讯作者：
et al.

Spontaneous elicitation of potent anti-tumor immunity and eradication of established tumors by administration of DNA encoding soluble transforming growth factor-beta II receptor without active antigen-sensitization

通过施用编码可溶性转化生长因子-β II 受体的 DNA，无需主动抗原致敏，自发引发有效的抗肿瘤免疫并根除已形成的肿瘤

DOI：
发表时间：
2006
期刊：
Cancer Immunol. Immunother. 55
影响因子：
0
作者：
Kontani K;Fujita T;Sawai S;Tezuka N;Fujino S.;Yamauchi A;Yokomise H
通讯作者：
Yokomise H

Alpha-internexin as a corneal autoantigen in spontaneous autoimmune keratitis mouse model

α-internexin 作为自发性自身免疫性角膜炎小鼠模型的角膜自身抗原

DOI：
发表时间：
2006
期刊：
Invest.Ophthalmol.Vis.Sci. 47
影响因子：
0
作者：
Yamada K;et al.;杉浦英志;Yamada k. et al.;Hattori T. et al.
通讯作者：
Hattori T. et al.

Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells

DOI：
10.1167/iovs.05-0110
发表时间：
2006-03-01
期刊：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子：
4.4
作者：
Keino, H;Takeuchi, M;Stein-Streilein, J
通讯作者：
Stein-Streilein, J

A young patient with invasive small cell carcinoma of the urinary bladder : a case report

一名患有浸润性膀胱小细胞癌的年轻患者：病例报告

DOI：
发表时间：
2005
期刊：
Hinyokika Kiyo 51
影响因子：
0
作者：
Kontani K;Kajino K;Huangi CL;Fujino S;Taguchi O;Yamauchi A;Yokomise H;Ogasawara K;Hasegawa Y. et al.;Kato Y.et al.
通讯作者：
Kato Y.et al.