Signal transduction for liver cell proliferation and its regulation.
Signal transduction for liver cell proliferation and its regulation.
批准号:
63480201
负责人:
HAYASHI Norio
金额:
$1.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1988
资助国家:
日本
项目状态:
已结题
起止时间:
1988 至 1989
中文摘要
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英文摘要
Liver regeneration provides a good model for studying cell growth and disserentiation. During rat liver regeneration induced by carbon tetrachloride administration, the protein kinase Calpha subspecies was activated in a heterogeneous fashion, a higher number of hepatocytes expressing the protein kinase Calpha subspecies being detected in the pericentral zone than in the periportal zone. This zonal heterogeneity became maximal at 24 h after the treatment. The distribution of hepatocytes expressing the protein kinase C subspecies was roughly coincident with that of hepatocytes exhibiting DNA synthesis. These results suggest that protein kinase C may play a crucial role in liver regeneration.
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古澤俊一、他: "肝再生過程における細胞性癌遺伝子発現動態の検討" 肝臓. 29. 377-381 (1988)
Shunichi Furusawa 等:“肝脏再生过程中细胞癌基因表达动态的检查”Liver. 29. 377-381 (1988)
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Sasaki Y.et al.: "Cellular analysis of c-Ha-ras gere exprission during liver regenergtion by in situ hubricigation." Hepatology. 10. 494-500 (1989)
Sasaki Y.et al.:“通过原位 hubricigation 进行肝脏再生过程中 c-Ha-ras gere 表达的细胞分析。”
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Sasaki Y, et al.: "Cellular analysis of c-Ha-ras gene expression during liver regeneration by in situ hybridization." Hepatology 10:494-500, 1989.
Sasaki Y 等人:“通过原位杂交对肝再生过程中 c-Ha-ras 基因表达进行细胞分析。”
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Ito T, et al.: "Sequential proto-oncogene expression during regeneration un rat stomach." Gastroenterology.
Ito T 等人:“大鼠胃再生过程中原癌基因的连续表达。”
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通讯作者:
古澤俊一: 肝臓. 29. 377-381 (1988)
古泽俊一:肝脏。29. 377-381 (1988)
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