Creation of New Lead Compounds using Natural Resources and Metal Nanoparticle Catalysts

我们完成了发现前所未有的化学转化，并通过一个一步反应的物质存在于提取物的海洋海绵岩（Strongylophora）SP。化学多样化的物质存在于天然产物提取物与热处理的乙醇产生了一个新的，意想不到的四环溴吡咯-咪唑衍生物，外消旋-6-OEt-cylindradine A。我们还证实，它起源于天然存在的（-）-cylindradine A通过一个新的反应模式。此外，（-）-dibromophakellin和4，5-dibromoproroleyle 2-carboxylic acid以及（-）-cylindradine A均为首次报道。并对其可能的反应机理和生物活性进行了研究。结果表明，天然产物提取物中存在的物质的直接化学多样化可以是发现新化合物的快速和有用的策略。

We accomplished to discover unprecedented chemical conversion and produce a new compound through a one-step reaction of substances present in the extract of marine sponge Petrosia (Strongylophora) sp.Chemical diversification of the substances present in the natural product extract with heat-treated EtOH produced a new, unexpected tetracyclic bromopyrrole-imidazole derivative, rac-6-OEt-cylindradine A. We also confirmed that it originated from naturally occurring (-)-cylindradine A via a new reaction pattern. Moreover, (-)-dibromophakellin and 4,5-dibromopyrrole-2-carboxylic acid as well as (-)-cylindradine A were reported herein for the first time in this genus. Studies on the possible reaction mechanism and bioactivities were also conducted. The results indicate that the direct chemical diversification of substances present in natural product extracts can be a speedy and useful strategy for the discovery of new compounds.