Herbal teas rich in polyphenols for protective modulation of initial oral bioadhesion

膜是最初的蛋白质和糖蛋白层，几乎是在接触口腔液体的所有表面上瞬间形成的。它具有保护作用，并调节细菌的定植，从而引发和发展龋齿和腐蚀性矿物质流失。最佳预防龋齿和腐蚀仍然是一个相当大的挑战，尽管由于现代饮食，这些疾病的发病率很高。在这方面，具有高度生物兼容性和可持续性的创新生物学概念具有越来越大的相关性。一种方法是富含多酚及其成分的草药。研究表明，一些草药提取物可以改变膜的超微结构，形成更厚、更致密的电子致密层。从而优化了对诺克索侵蚀的保护。本项目的目的是系统地表征到目前为止尚未用于预防牙科的药用多酚植物提取物。这适用于组合物以及对生物黏附过程和膜层形成的影响。因此，有效的植物提取物和植物成分将被鉴定。在第二步中，将开发新的和简单的预防性牙科概念。

The pellicle is the initial protein and glycoprotein-layer which is formed almost instantaneously on all surfaces exposed to the oral fluids. It has protective properties and modulates bacterial colonization and therewith initiation and progression of caries and erosive mineral loss. Optimal prevention of caries and erosions is still a considerable challenge despite the high prevalence of these diseases due to modern diet. In this context innovative biological concepts of high bio-compatibility and sustainability are of increasing relevance. One approach are herbal drugs rich in polyphenols and their components. It has been shown that some herbal extracts modify the ultrastructure of the pellicle yielding a thicker and more electron dense layer. Therewith the protection against erosive noxae is optimized. The aim of the present project is to characterize officinal polyphenolic plant extracts systematically that have not been adopted in preventive dentistry until now. This applies for composition as well as for the impact on bioadhesion-processes and pellicle formation. Thereby, effective plant extracts and plant components will be identified. In a second step, new and simple concepts for preventive dentistry will be developed.