CXC chemokine receptors and regulation of platelet function, thrombo-inflammation and myocardial remodelling in I/R (B01)

我们希望分析CXCR 4/ACKR 3的相互作用，并确定血小板功能的ACKR 3相互作用组和潜在的信号通路。小鼠实验将集中于心肌梗死中合并症的影响和血小板对血栓炎症和心脏缺血/再灌注（I/R）后心室重塑的影响。实验研究将通过研究CXCR 4/ACKR 3在急性心肌梗死患者中的作用来补充。该项目的翻译方面将是将ACKR 3定义为I/R中的潜在治疗靶点。

We want to analyse the CXCR4/ACKR3 interplay as well as identify the ACKR3 interactome and underlying signalling pathways for platelet function. Mouse experiments will focus on the influence of comorbidities in myocardial infarction and the impact of platelets on thrombo-inflammation and ventricular remodelling following ischaemia/reperfusion (I/R) of the heart. The experimental research will be complemented by studying the role of CXCR4/ACKR3 in humans with acute myocardial infarction. The translational aspect of the project will be to define ACKR3 as potential therapeutic target in I/R.