Reagents for spatiotemporal control over TRPM/TRPC function (P24)

在P24项目中，我们将产生新的化学试剂，用来调节和研究天然的Trp通道。我们将开发在生理环境中以高时空精度调制Trp通道的光开关试剂，既使用经典的方法(对已知的药效团进行空间要求很高的光开关)，又开发一种新的、通用的方法(生物定位光控制)。我们还将合成色氨酸调节剂的光亲和标记衍生物，以表征其结合部位，并为CRC提供持续的合成支持。因此，P24促进了天然Trp通道调制器的普遍发现、开发、表征和使用。

In project P24 we will generate new chemical reagents with which to modulate and study native TRP channels. We will develop photoswitchable reagents for modulating TRP channels in their physiological contexts with high spatiotemporal precision, both using classical approaches (sterically demanding photoswitches on known pharmacophores) and developing a novel, general approach (biolocalisation photocontrol). We will also synthesise photoaffinity label derivatives of TRP modulators to characterise their binding sites, and provide ongoing synthetic support to the CRC. P24 therefore promotes the general discovery, development, characterisation and use of modulators for native TRP channels.