Clinician Scientist School Lübeck: Connecting Brain, Metabolism, and Inflammation (BMI) – Mechanisms and Disease Expression

莱尔贝克大学（UzL）是一所教师无国界的生命科学大学，以临床医生和致力于转化研究的基础科学家之间的无缝，并排合作为特色。UzL在其研究中优先考虑临床科学家（CS）的培训和整合。它一直在严格地追求整合其所有外部资助的研究联盟的研究轮岗。它还建立了一个内部研究轮岗计划。获得这些轮换职位的竞争非常激烈，而且需求明显高于可用的职位。与石勒苏益格-荷尔斯泰因的医师委员会合作，UzL开发了一个课程，将临床培训和保护研究时间整合在皮肤病学和内科委员会认证中。该委员会批准的课程在全国范围内是第一个正式运作的此类项目，并已成为德国综合培训课程的蓝图，由Medizinischer Fakultätentag的CS工作组作为l<s:1>贝克模型进行宣传。为了进一步改善大学及其他地方的计算机科学培训，必须建立集中机构，在全校范围内按照明确的规则和标准统筹和监督计算机科学培训。这样一个机构，执行规则和培训标准，是在所有专业实施董事会核准的长期课程的先决条件。因此，我们建议建立临床科学家学院<s:1>贝克（CSSL）。CSSL将是一个覆盖整个uzl的中央基础设施。协调、统一和监督CS的培训。培训将根据临床/研究联合课程和可转移技能培训计划进行。CS学员的研究培训将是跨学科的，由临床医生和基础科学家组成的导师小组进行。这将有助于培养医学和科学方面的医生，为开设诊所和多学科研究小组奠定基础。CSSL项目还将使在科学新兴临床科室接受培训的住院医生能够获得本部门以外知名科学家的培训。通过这种方式，CSSL将把高质量研究的核心传播到校园的所有临床科室。要求轮换职位的cst将进行连接UzL研究重点的脑，行为，代谢和感染与炎症的项目。他们将研究大脑、代谢和免疫系统之间的双向串扰，以及神经退行性、代谢和自身免疫性疾病的相互促进作用，遗传学和组学方法将作为跨项目的重要联系。具体项目和轮岗将通过包括外部评审和内部CSSL监督委员会在内的竞争程序分配。

The University of Lübeck (UzL) is a faculty boundary-free Life Science University featuring the seamless, side-by-side collaboration between clinicians and basic scientists dedicated to translational research. The UzL prioritizes the training and integration of clinician scientists (CS) in its research. It has rigorously been pursuing the integration of research rotation positions in all of its extramurally funded research consortia. It has also established an intramural research rotation program. Obtaining one of these rotation positions is highly competitive, and the demand is significantly higher than the positions available.In collaboration with the Board of Physicians in Schleswig-Holstein, the UzL has developed a curriculum integrating clinical training and protected research time for the Board certification in Dermatology and Internal Medicine. This Board-approved curriculum nationwide is the first such program officially operating and has become a blueprint for integrated training curricula in Germany, propagated by the task force CS of the Medizinischer Fakultätentag as the Lübeck Model.To further improve the training of CS at the UzL and beyond, the establishment of centralized bodies, institution-wide orchestrating and monitoring the training of CS according to clearly defined rules and standards is imperative. Such a body, enforcing rules and training standards, is a prerequisite to implement long-lasting, Board-approved curricula through all specialties. We therefore propose to establish the Clinician Scientist School Lübeck (CSSL). The CSSL will be a UzL-wide, central infrastructure. It will coordinate, unify and monitor the training of CS. The training will be conducted according to the combined clinical/research curriculum and through a transferable skills training program. The research training of CS trainees (CST) will be interdisciplinary and conducted by mentor groups combining clinician and basic scientists. This will facilitate the training of physicians in medicine and science to lay the foundation to run both a clinic and a multidisciplinary research group. The CSSL program will also enable residents in training in scientifically emerging clinical departments to obtain training by well-established scientists outside of their department. By this, the CSSL will spread nuclei of high-quality research throughout all clinical Departments on campus.The CSTs on the requested rotation positions will conduct projects bridging the UzL research foci Brain, Behavior, and Metabolism and Infection and Inflammation. They will investigate the bidirectional crosstalk between brain, metabolism, and immune system and the mutually promoting effects of neurodegenerative, metabolic, and autoimmune disorders with genetics and omics approaches serving as an important link across projects. The specific projects and rotation positions will assigned through a competitive process including external reviewers and an internal CSSL supervisory board.