New generation laser scanning confocal microscope for multimodal deep tissue and functional imaging

德累斯顿工业大学在过去20年里招聘了大约40名教授(其中两名拥有享有盛誉的亚历山大·冯·洪堡教授头衔)和30多个研究小组，坚定地致力于健康科学、生物医学和生物工程的研究领域。主要研究领域是干细胞生物学、组织和器官修复(再生医学)、生物技术和细胞和组织的生物物理学。许多实验方法涉及分子、细胞、组织和整个生物体的光学显微镜研究。在我们这个时代，特别有用的技术不仅可以成像，还可以对活的生物样本中的动态过程进行功能研究。我们在这里应用的仪器是一款出色的多功能显微镜系统，它提供了经典的共焦成像模式、通过2p激发进行的深度组织成像(最高可达1 mm)和灵活的光谱检测，以及基于新的时间测量概念和高效的单光子探测器来确定荧光寿命。在以下段落中，将概述德累斯顿生物研究的潜在益处。

The Technical University Dresden has made a strong commitment to the research fields of Health Sciences, Biomedicine and Bioengineering by recruiting about 40 professors (among them two world-leading scientists that hold a prestigious Alexander von Humboldt Professorship) and more than 30 research groups in the past 20 years. Main fields of research are the biology of stem cells, tissue and organ repair (regenerative medicine), biotechnology and the biophysics of cell and tissue organization. Many experimental approaches involve the light microscopical investigation of molecules, cells, tissues and whole organisms. Especially useful in our days are technologies that not only allow imaging but functional studies on dynamic processes within living biological specimen as well. The instrument we apply for here is an outstanding versatile microscope system that offers access to classical confocal imaging modalities, deep tissue imaging (up to 1mm) by 2p excitation and flexible spectral detection and the determination of fluorescence lifetimes based on a new time measurement concept and highly efficient single photon detectors. In the following paragraphs the potential benefit for the biological research in Dresden will be outlined.