Biofunctional Assessment and Interventional Treatment of Coronary Inflammation guided by Magnetic Resonance Imaging

磁共振成像（MRI）在心血管疾病中的诊断潜力正在稳步显现。此外，由于技术的发展、无电离辐射以及与荧光透视相比具有上级软组织对比度，MRI已进入介入应用阶段。在该提案中，我们建立了一个由具有分子成像专业知识的介入心脏病专家和具有公认的尖端MR序列、导管跟踪和线圈开发跟踪记录的医学物理学家组成的联盟。我们的目标是通过分子成像、冠状动脉血管壁的血管内高分辨率MRI以及植入支架或新一代药物洗脱支架（DES）以“密封”炎症部位的介入性实时MR引导冠状动脉介入治疗，实现冠状动脉斑块炎症的实时评估。我们最终设想完全MR引导的调查和介入治疗的炎症，因此潜在的脆弱冠状动脉病变。

Magnetic resonance imaging (MRI) is steadily emerging its diagnostic potential in cardiovascular disease. Furthermore, MRI has entered the stage for interventional application due to technical developments, absence of ionizing radiation, and superior soft tissue contrast compared to fluoroscopy. In this proposal, we build a consortium of interventional cardiologists with expertise in molecular imaging and medical physicists with an acknowledged track-record of cutting edge MR-sequence, catheter-tracking and coil development. We aim to enable real-time assessment of coronary plaque inflammation with molecular imaging, intravascular high-resolution MRI of the coronary vessel wall, as well as interventional real-time MR-guided coronary intervention with implantation of scaffolds or new generation drug eluting stents (DES) to “seal” the inflamed site. We ultimately envision fully MR-guided investigation and interventional treatment of inflamed and therefore potentially vulnerable coronary lesions.