Identification and characterization of MOF interaction and substrate repertoire (B03)

组蛋白乙酰化是一种重要的表观遗传修饰，在多种细胞过程中发挥着不同的作用。M0F（Males absent On the First）是负责组蛋白H4赖氨酸16（H4K16ac）沉积的主要赖氨酸乙酰转移酶。我们发现，MOF双重定位于细胞核和线粒体。我们将研究线粒体MOF亚复合物的功能，并研究线粒体蛋白质的MOF乙酰化对线粒体功能的影响。

Histone acetylation is a prominent epigenetic modification playing diverse roles in several cellular processes. MOF (Males absent On the First) is the major lysine acetyl transferase responsible for deposition of histone H4 lysine 16 (H4K16ac). We found that MOF dually localizes to the nucleus and mitochondria. We will study the function of mitochondrial MOF subcomplexes and investigate the consequences of MOF acetylation of mitochondrial proteins on mitochondrial functions.