Regulation of immune responses by hypothalamic hormones

我们研究了下丘脑激素以及一些垂体激素和阿片肽对免疫相关细胞（如巨噬细胞、自然杀伤细胞和淋巴细胞）活性的影响，主要结果如下：1）促肾上腺皮质激素释放激素（CRH）和阿片肽增强低浓度干扰素（IFN）潜伏激活的巨噬细胞的抗肿瘤活性。γ和细菌脂多糖。阿片受体拮抗剂纳洛酮可阻断阿片肽的作用，但不能阻断CRH的作用; 2）CRH和阿片肽可促进人单核细胞和淋巴细胞产生IFN-γ和IFN-α。促肾上腺皮质激素（ACTH）和糖皮质激素（地塞米松）抑制IFN的产生：3）促甲状腺激素释放激素（TRH）和促甲状腺激素（TSH）增强凝集素诱导的T和B细胞增殖; 4）TRH不影响体内抗体反应，但中断解聚人γ球蛋白诱导的耐受。我们正在研究许多其他激素对各种免疫反应的影响，但我们获得的具体结果仍然很少。调查正在进行中。现象学结果的积累、对它们的分析和逻辑构建将需要理解心理-神经-内分泌-免疫网络的生物学重要性。

We investigated the effects of hypothalamic hormones, and also those of some pituitary hormones and opioid peptides, on the activity of immune-related cells, such as macrophages, natural killer cells, and lymphocytes.Main results obtained are as follows : 1) Corticotropin-releasing hormone (CRH) and opioid peptides enhanced the antitumor activity of macrophages latently activated by low concentrations of interferon (IFN) -gamma and bacterial lipopolysaccharide. Naloxone, an antagonist of opioids, abrogated the effect of opioid peptides, but not that of CRH ; 2) CRH and opioid peptides enhanced thd production of IFN-gamma and IFN-alpha by human monocutes and lymphocytes. Corticotropin (ACTH) and a glucocorticoid (dexamethasone) inhibit the IFN production : 3) Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) augmented the lectin-induced proliferation of T and B cells ; and 4) TRH did not affect the in vivo antibody response, but interrupted the tolerance induction in mouse by deaggregated human gamma globulin. We are studying the effect of many other hormones on various immune responses, but concrete results we obtained are still very few. Investigations are underway. Accumulation of phenomenological results, analysis for them, and logical construction will be required for understanding the biological importance of the psycho-neuro-endocrino-immune network.