Neurochemical and neurophysiological mechanisms in the interaction of reward processing with bottom-up and top-down networks: The role of dopamine and E/I balance (B07)

项目B07调查了健康受试者和精神分裂症患者自下而上和自上而下视觉注意与奖励过程的相互作用。B07项目的主要焦点在于这种相互作用的神经生理和神经化学机制。我们将使用多巴胺受体的神经药物调节，结合同时EEG-fMRI、多通道TAC和高级电场建模的逐次试验耦合来探索神经振荡在这一过程中的原因，并使用磁共振波谱来表征视觉皮质和ACC中谷氨酸浓度与视觉选择的关系。

Project B07 investigates the interaction of bottom-up and top-down visual attention with reward processes in healthy subjects and patients with schizophrenia. The main focus of project B07 lies on the neurophysiological and neurochemical mechanisms of this interaction. We will use neuropharmacological modulation at the dopamine receptor together with trial-by-trial coupling of simultaneous EEG-fMRI, multichannel-tACS and advanced electrical field modeling to probe the causal role of neural oscillations in this process and MR-Spectroscopy to characterize the relationship of glutamate concentrations in the visual cortex and the ACC with visual selection.