Endocine cell tumors of gastrointestinal tract : characteristics and histogenesis

在过去的两年中，这个特殊的项目，收集和分析日本胃肠道内分泌细胞肿瘤。胃肠道内分泌细胞肿瘤分为类癌（CD）、低度恶性肿瘤和内分泌细胞癌（ECC）。高度恶性肿瘤建立了两种肿瘤的组织学鉴别诊断. CD主要来源于未成熟的内分泌细胞。ECC可能来源于黏膜管状腺癌中的肿瘤性内分泌细胞、全能干细胞、CD或未成熟的内分泌细胞。第一条途径可能是最常见的，其次是第二条。根据类癌发生部位的不同，建立了新的分类。日本患者有不同于欧美患者的特点和发病率分布.从人食管、胃和直肠癌细胞中建立了4个细胞系，其中4个细胞系CK-BB高表达，2个细胞系芳香族L-氨基酸脱羧酶和NSE低表达，4个细胞系C-myc、N-myc和L-myc无扩增，2个细胞系c-myc mRNA表达。

During the period of past two years of this particular project, endocrine cell tumors of the gastrointestinal tract of Japanese were collected and analyzed.1. Endocrine cell tumors of the gastrointestinal tract were divided into two groups : carcinoid tumor(CD), low-grade malignacy and endocrine cell carcinoma(ECC). high-grade malignancy. Histological differential diagnosis between these two entities wasestablished.2. CD was suspected to be mainly derived from immature endocrine cells. ECC were hypothesized to derive from neoplastic endcrine cell in mucosal tubular adenocarcinoma, totipotential stem cell, CD, or immature endocrine cells. The first pathway was suspected to be most frequent, followed by the second.3. New classification of carcinoid tumors according to different ocurring sites wasestablished. Japanese patients have characteristic and incidence of distribution different from that of Europeans and Americans.4. Four cell lines were established from human esophageal, gastric and rectal ECC.They showed high levels of CK-BB (4 lines), low levels of aromatic L-amino-acid decarboxylase(2 lines) and NSE (3 lines), no amplification of C-myc, N-myc and L-myc (4lines) and expression of c-myc mRNA (2 lines).