Physical Activity and Immune Senescene in Men

一项横断面调查研究了习惯性耐力锻炼者是否比久坐不动的老年人保留了更高水平的T细胞功能。受试者均为男性，包括17名老年跑步者、16名年轻对照者和19名老年对照者（平均年龄分别<plus-minus>为63.8 <plus-minus>± 3.3、23.6 <plus-minus>± 1.6和65.8 ± <plus-minus>3.5岁）。运动后至少36 h采集外周血样本。组间比较仅对非吸烟者的数据进行，采用单因素方差分析和Bonferroni调整进行事后多重比较。淋巴细胞功能评估为每个主要应答细胞的调整活性以及通常的未调整活性。与年轻受试者相比，两个老年组的循环中CD 3 ^+和CD 8 ^+细胞计数均较低（组效应：分别为P= 0.029，P= 0.001），CD 4/CD 8比值有较高的趋势，但活化的CD 3 ^+细胞和“记忆”CD 4 ^+和CD 8 ^+细胞的百分比较高（均为P&lt;0.001）。普罗利夫 ...更多信息 老年人对植物血凝素（PHA）、美洲商陆有丝分裂原（PWM）和同种异体抗原（混合淋巴细胞反应）的反应明显降低（对于未校正的活动，分别为P&lt;0.001、P&lt;0.001和P= 0.024）。在老年久坐受试者中IL-2的产生倾向于减少（P= 0.058 vs年轻受试者）。然而，自然杀伤细胞活性没有受损，IL-1 β，IFN-γ和IL-4的产生在久坐的老年受试者中保持不变。活动和久坐的老年人组之间的比较表明，免疫活性细胞的循环计数没有差异。然而，活跃的老年受试者表现出对PHA（未调整P= 0.016，调整活动P= 0.034）和PWM（分别为P= 0.011和P= 0.040）的显著更大的增殖反应，以及更高的IL-2（P= 0.021），IFN-γ（P= 0.015）和IL-4产生率（P= 0.012）。这些结果表明，在以后的生活中，耐力训练与循环T细胞功能和相关细胞因子产生的某些方面的年龄相关性下降较小有关。少

A cross-sectional survey examined whether habitual endurance exercisers retained a higher level of T cell function than sedentary individuals in old age. Subjects, all male, comprised 17 elderly runners, 16 young controls and 19 elderly controls (mean ages <plus-minus> SD : 63.8 <plus-minus> 3.3,23.6 <plus-minus> 1.6, and 65.8 <plus-minus> 3.5, yr, respectively) . Samples of peripheral blood were collected at least 36 h after exercise. Group comparisons were made on data from non-smokeres only, using one-way ANOVA and a Bonferroni adjustment for post-hoc multiple comparisons. Lymphocyte functions were assessed as adjusted activity per major responding cell as well as the usual unadjusted activity. In comparison wtih the young subjects, both elderly groups had lower circulating CD3^+ and CD8^+ counts (group effects : P=.029, P=.001, respectively) , with a trend to a higher CD4/CD8 ratio, but higher percentages of activated CD3^+, and "memory" CD4^+ and CD8^+ cells (all, P<.001) . Prolif … More erative responses to phytohemagglutinin (PHA) , pokeweed mitogen (PWM) and alloantigens (mixed lymphocyte reaction) were markedly reduced in the elderly (for unadjusted activities, P<.001, P<.001 and P=.024, respectively). IL-2 production tended to be decreased in the elderly sedentary subjects (P=.058 vs young subjects) . However, natural killer cell activity was not impaired, and IL-1beta, IFN-gamma and IL-4 production remained unchanged in the elderly sedentary subjects. Comparison between the active and sedentary elderly groups showed no differences in circulating counts of immunocompetent cells. However, the active elderly subjects demonstrated significantly greater proliferative responses to PHA (P=.016 for unadjusted and P=.034 for adjusted activity) , and to PWM(P=.011 and P=.040, respectively) , and higher rates of IL-2 (P=.021), IFN-gamma (P=.015) and IL-4 production (P=.012) . These results suggest that endurance training in later life is associated with a lesser age-related decline in certain aspects of circulating T cell function and related cytokine production. Less