Bacteriological study for periodontal disease proceeding

这项纵向研究的目的是评估使用某些临床和微生物变量来预测2年期间牙周病的进展。本研究选取30名年龄22-31岁的牙科学生，将22名牙龈炎患者分为2组，龈下菌斑有艾肯氏菌腐蚀组15名（簇1:C1），无艾肯氏菌腐蚀组7名（簇2:C2）。在每6个月的5次访问中，每次对受试者进行临床和微生物学检查。结果显示，在整个纵向研究中，C1组和C2组的临床参数无显著差异。多元回归分析显示，牙龈下细菌因素对牙龈指数（GI）评分和牙龈袋深（PD）从基线年到1年的变化解释的方差最高（38%,39%）。对于GI和PD在1年内的变化，运动棒和中间普雷沃氏菌具有显著的回归系数。逐步logistic回归分析结果显示，运动杆与PD的增加呈显著正相关，且有非常高的比值（106.4）。这些结果表明，运动杆的存在和比例与牙龈炎症的增加显著相关。这项研究表明，运动棒可以可靠地用于预测牙龈炎的进展。

The aim of this longitudinal study was to evaluate the use of certain clinical and microbiological variables to predict periodontal disease proceeding during a 2-year period. 22 subjects with gingivitis of 30 dental students (aged 22-31 at baseline) participated in this study were divided into 2 groups, 15 subjects with Eikenella corrodens in subgingival plaque (Cluster 1 : C1) and 7 subjects without E.corrodens (Cluster 2 : C2). The subjects were examined clinically and microbiologically at each of the 5 visits every 6 months. The results showed that there was no significant differences of clinical parameters in C1 and C2 groups throughout the longitudinal study. The analysis using the multiple regression method showed that the variance explained by the subgingival bacteria factors was highest (38%, 39%) for the change in gingival index (GI) scores and pocket depth (PD) from baseline yearto 1 year. For the change of GI and PD over 1 year, motile rods and Prevotella intermedia had a significant regression coefficient. The result of stepwise logistic regression analysis indicated that motile rods was significantly positive associated with the increase in PD,and had very higher odds (106.4). These results indicate that both presence and proportion of motile rods are significantly associated with the increase in gingival inflammation. This study suggests that motile rods can be used reliably to predict gingivitis progression.