Preventive effect of involutional osteoprosis in exercised at different ages

为探讨人体更年期骨质疏松症的预防作用，采用显微光密度测定、力学性能测试、血清钙代谢分析等方法，观察了不同年龄运动对骨质疏松症的不同反应。将小鼠分为5组：1）生长期运动组（10- 30周）（A组），2）成熟期运动组（31- 50周）（B组），3）老龄期运动组（51- 70周）（C组），4）全周期运动组（10- 70周）（D组）。5）控制（非运动组）（E）。本研究的结果总结如下：A、D、E组大鼠体重显著高于B组; 2）E组大鼠骨密度显著低于其他4组; 3）C、E组大鼠CTI有降低趋势; 4）E组大鼠的断裂力和最大应力显著低于A组。B组和D组的变形率显著高于A组; 6）弹性率E组高于其他各组，E组与A组和D组差异有统计学意义; 7）C-甲状旁腺素、CT、Ca与E组比较差异无统计学意义。E组P值有降低趋势，提示各年龄段运动对人体退行性骨质疏松均有预防作用，其效果表现为老年期运动组优于其他运动组。但是，这些结果似乎表明，老年期运动组与其他运动组之间的运动中骨的差异。

In order to clarify the preventive effect of involutional osteoprosis in human, different responses to exercise at ages were examined by microdensitmetry, mechnical property test, analyzes of Ca metabolism in serum. The mice were divided into the following five groups : 1) growth period exercise group (10-30w) (A) ; 2) maturity period exercise group (31-50w) (B) ; 3) aged period exercise group (51-70W) (C) ; 4) all period exercise group (10-70W) (D) ; 5) control (non-exercise group) (E).The results of this study are summarized as follows :1) Body weight was fignificantly higher in A,D and E group than in B group.2) Bone density was significantly lower in E group than in other four groups.3) CTI showed tendency to be lower in C,E group than in other groups.4) Breaking force and U1timate stress were significant lower in E group than in A,B and D group.5) Deformation was significant higher in D group than in A group.6) Elasticity showed tendency to be E group than in other groups, significant difference between the E group and A or D group.7) There was no significant difference in C-PTH,CT,Ca between the E group and the exercise groups. But, P showed tendency to be lower in E group than in other groups.In summary, these results support the view that exercise at every age may be a prevention for involution osteoprosis in human being, its effect showed tendency to be aged period exercise group than other exercise group. But, these results seem to suggest that of bone in exercise make a difference between aged period exercise group and other exercise group.