Nanoelectromechanical Mass Spectrometry with Molecular Imaging

该项目旨在开发新技术，以同时测量单个分子的质量和构象。质谱法和高分辨率显微镜是独立的分析工具，广泛用于表征分子的化学和物理性质。该项目旨在开发基于先进纳米机电系统的新技术，该系统结合了这些互补仪器的能力。这将使分子质量和构象的同步测量具有纳米分辨率。与目前的质谱法相比，该技术可以在流体中操作并检测中性物质。这种能力上的重大变化可用于推进生物和医学研究。

This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.