Pathological investigation on human bladder epithelium

从313例身体解剖标本中获取肉眼看正常的膀胱，并进行显微镜检查。增生性病变，如布鲁恩窝和腺性膀胱炎，在所有年龄和性别的病例中都是常见的。柱状化生、立方状化生、鳞状化生等化生病变较少见。这两种类型的病变与年龄无关，但鳞状化生在女性中比男性更常见。4种病变的好发部位分别为三尖瓣和前壁。男性16.3%，女性10.6%；不典型增生男性6.8%，女性5.7%。这两种类型的病变在年龄较大的患者中比年轻患者更常见。两种类型的病变都与慢性炎症无关。1例男性发现原位癌。这些数据和膀胱图表明，这些良性的增生性和化生性病变都不是异型增生或原位癌的发展。我们研究了一些参与药物代谢、膜功能和其他细胞生理领域的酶在人膀胱中的表达，重点是肿瘤性病变。以碱性磷酸酶(ALP)降低和γ-谷氨酰转肽酶(GGT)、β-葡萄糖醛酸酶(&lt；β&gt；-Gl)、琥珀酸脱氢酶(SD)和葡萄糖-6-磷酸脱氢酶(G6PD)升高为特征。此外，不同细胞色素P450特异性抗体与微粒体环氧化物水解酶(MEHb)的结合在肿瘤中表现为共同的升高。

Urinary bladder that appeared normal macroscopically were obtained from 313 autoposy cases of both sexes and examined microscopically. Proliferative lesions such as Brunn's nests and cystitis glandularis were frequent in cases of all ages and both sexes. Metaplastic lesions such as columnar or cuboidal metaplasia and squamous metaplasia were less frequent. These two types of lesions were not related to age, but squamous metaplasia was more common in females than in males. The sites of predilection for there 4 types of lesions were the trihone and anterior wall. Hyperplasia was observed in 16.3% of the male and 10.6% of the female cases, and dysplasia in 6.8% of the male and 5.7% of the female cases. Both types of lesions were more frequent in older than younger cases. Neither type of lesions was related to chronic inflammation. One case of carcinoma in situ was found in a male. These data and mapping of the bladders indicated that none of these benign proliferative and metaplastic lesions were the development of dysplasia or carcinoma in situ.Expression of a number of enzymes involved in drug metabolism, membrane function and other areas of cellular physiology was investigated on the urinary bladder of man with emphasis on neoplastic lesions. Thransitional cell carctnoma were characterized by decreased alkaline phosphatase (ALP) and increased gamma glutamyl transpeptidase (GGT), <beta>- glucuronidase (<beta>-Gl), succinate dehydrogenase (SD) and glucose-6-phosphate dehydrogenase (G6PD). In addition, binding for antibodies specific for different cytochrome P450 species and microsomal epoxide hydrolase (mEHb) demonstrated a common elevation in tumors.