Virological and Clinicopathological Study on Non-A,non-B Hepatitis

非甲、非乙型肝炎病毒尚未确定。本研究旨在以一种迄今未见报道的特殊方式研究非甲非乙型肝炎的病原体。我们曾尝试在非甲非乙型肝炎患者的原代培养肝细胞和淋巴细胞中检测病毒，但迄今为止，我们还没有通过这种方法找到任何负责的病原体。其次，病毒性肝炎的流行病学研究显示，在急性散发性病毒性肝炎中，非甲非乙型肝炎的患病率最高，约占40%，输血后肝炎仅为过去2年发生的非甲非乙型肝炎。散发性和输血后类型的非甲非乙型肝炎并不少见，具有慢性化。然而，对这些患者的纵向随访研究显示，他们没有表现出在一些慢性B型肝炎患者中观察到的快速进展为肝硬化。需要进一步更长时间的随访研究来阐明这些患者的长期结局。

Non-A,non-B hepatitis virus(es) has not yet been identified. This study was to investigate the etiological agent(s) of non-A,non-B hepatitis in a special way hitherto not reported. We have tried to detect the virus(es) in the hepatocytes and lymphocytes of primary culture after being obtained from patients with non-A,non-B hepatitis, However, until now we could not find any responsible agent by this method. Further modifications of the culture medium or culter conditions seem to be needed.Next, the epidemiological study on viral hepatitis revealed that the prevalence of non-A,non-B hepatitis was the highest among the acute sporadic viral hepatitis, that accounted for approximately 40 % of them, and posttransfusion hepatitis was exclusively of non-A,non-B hepatitis so far experienced over the past 2 years. Non-A,non-B hepatitis of both sporadic and posttransfusion category was found not infrequently to have a chronicity. However, the longitudinal follow-up study for these patients revealed that they did not show a rapid progression to cirrhosis as observed in some of the patients with chronic hepatitis type B. Further longer follow-up study will be needed to clarify the long-term outcome of these patients.