Basic research on physiology and pathophysiology of the Eustachian tube function

针对听力管功能障碍性疾病的功能和发病机制研究较少的情况，我们继续研究声管探测仪的研制，论文编号：57870102。在本研究中，我们进行了下一步的研究，以研究中耳腔内的气体代谢和听管功能。一般来说，耳道鼓起到中耳腔被解释为一个器官，在环境压力下将空气从外部吸入中耳腔。然而，在测量中耳腔中的CO_2时增加的几个负荷使我们了解到，在常压下，通过打开和关闭与环境中吞咽运动相关的听管，没有完全从听管供应到中耳腔的空气，中耳腔内存在作为空洞性质的特定的海绵状气体代谢，以及听管具有将其呼出到外部的作用。1)这是u…进一步了解，正常成人中耳腔的PO_2值约为53毫米汞柱，约相当于大气圈的1/2。2)中耳腔中的PO_2无明显变化。3)豚鼠鼓泡内固定传感器后发现，即使在100%氧气覆盖下吞咽运动后，气体也不会流入中耳腔，但在大气球压力不同的情况下，通过耳道的气体交换是存在的。吞咽运动后中耳腔PO_2升高，氧分压升高至100 MMH_2O左右。4)在睡眠状态下测定人的PO_2时，中耳腔PO_2值无变化，但中耳腔压力升高。认为这是由CO_2扩散引起的。当出现吞咽运动时，中耳腔内的压力恢复到正常压力。综上所述，正常的听管功能有一种趋势，即由于静息状态下闭合的听管而使中耳腔内的气体压力升高，即通过吞咽运动打开中耳腔，使其呼入大气层。换句话说，由于觉醒时通过吞咽运动打开耳道而不能抓住中耳腔内压力升高的现象，但中耳腔具有特定的气体代谢，通过在睡眠时中耳腔内压力增加等，从而使听管作为其排出管存在。较少

Aiming at few researches for thr function and pathogenesis of auditory tube dysfunction diseases, we have continued to study the development of a sonotubometer with our study thesis No. 57870102. In the present study, we proceeded to the next step to study gas metabolism and auditory tube function in the middle ear cavity. In general, the auditory tube bulonging to the middle ear cavity has been explained like an organ to enspire the air under the emvironmental pressure into the middle cavity from outside. However, several loads added while measuring CO_2 in the middle ear cavity mad us understand the air not supplied into the middle ear cavity from the auditory tube completely by opening and closing of the auditory tube in association with deglutition movement in the environment under the ordinary pressure, the existence of specific cavernous gas metabilism as a cavernous properity in the middle ear cavity, and the auditory tube haveing a role to expire it into the outside.1) It was u … More nderstood that po_2 values in the middle ear cavity in normal adults were about 53 mmhg equivalent to about 1/2 of the atomosphere.2) po_2 in the middle ear cavity showed no changes by opening and closing of the auditory tube in association with wsallowing movement.3) It was shown after fixiation of a sensor in the tympanic bulla in the guinea pigs that hte gas was not flowed into the middle ear cavity even after swallowing movements by covering their head with 100% oxygen but gas exchange via the auditory tube existed in the case of a difference in the atomospheric pressure caused by rise of po_2 in the middle ear cavity after swallowing movements by increasing the oxyten pressure to about 100 mmH_2o.4) PO_2 values showed no changes but the pressure in the middle ear cavity was increased when po_2 was determined in humans while sleeping, which was considered to be caused by CO_2 diffusion. The pressure in the middle earcavity was recovered to the normal pressure when deglutition movements occurred.In conclusion, there is a tendency of normal auditory tube function simply to heighten the gaseous pressure in the middle ear cavity due to closed auditory tube at rest, in which the auditory tube is opened by deglutition movements to expire it into the atomosphere. In other words, a phenomenon to heighten the pressure in the middle ear cavity cannot be grasped owing to opened auditory tube by deglutition movements at awakening but the middle ear cavity has specific gas metabolism by heightened pressure in the middle ear cavity at slooe, etc. so that the auditory tube exists as its discharging tube. Less