Tissue Changes Around Single-crystal Sapphire Implant Following Plaque Accumulation.

本研究的目的是评估与菌斑聚集相关的种植体周围组织的临床和组织学变化。9只猕猴下颌无牙区植入2颗单晶蓝宝石种植体，植入后1个月建立上层建筑。通过在种植体和天然牙周围放置结扎器让菌斑在一侧积聚，而不控制菌斑，另一侧继续菌斑控制9个月。种植牙和有菌斑堆积的天然牙临床参数均有不同程度的增加。组织学上，牙龈内可见不同程度的炎症反应，但骨-种植体界面完好。另一方面，种植体和有菌斑控制的牙齿的临床参数值较低。种植体周围组织和天然牙周组织中几乎没有炎症反应。这些发现表明，菌斑控制对于维持种植体周围组织的健康至关重要，并表明种植体周围牙周组织具有与固有牙龈相似的屏障特性，以抵御微生物的入侵。

The purpose of this study was to evaluate clinical and histological changes of peri-implant tissuse associated with plaque accumulation. Two single-crystal sapphire implants were inserted into the mandibular edentulous area and the super-structure was set 1 month postinsertion in each of 9 monkeys. Plaque was allowed to accumulate at one side by placing ligature around the implant and natural teeth without plaque control and at the other side plaque controlwas continued for 9 months. Both of the implant and natural teeth with plaque accumulation showed increase in clinical parameters. Histologically, various degrees of inflammatory reaction were seen in the gingiva, but bone-implant interface was intact. On the other hand, the implant and teeth with plaque control showed low values in clinical parameters. Inflammation was scarcely seen in the tissue around implant and natural teeth.These findings demonstrate that plaque control in essential for maintaining health of peri-implant tissuse and suggest that peri-implant gingiva possesses simolar barrier properties against microbial invasion to those of the inherent gingiva.