A study on the development of new bone a angmentation material composed of biodegradable poly-lactic acid and hydroxylapatite

为了开发一种新型的骨强化材料，以生物可吸收多聚酸(PLA)、羟基磷灰石(HA)和脱钙大鼠股骨颗粒(DP)为材料制备了一些复合材料，并对其骨组织反应进行了组织学评价，将这些复合材料植入12周龄Wistar大鼠的顶骨和人的骨膜下，以微孔过滤器为支架。组织学检查显示，聚乳酸-羟基磷灰石复合材料植入后未见骨形成，而聚磷灰石复合材料在宿主骨表面形成了明显的新骨形成，提示聚磷灰石复合材料是一种很有前途的新型骨强化材料，采用微孔滤膜支架的聚磷灰石复合材料可能是一种可预测的骨强化方法。

In order to develop a new bone augmentation material, some composite materials were fabricated from bioabsorbable polytactic acid (PLA), hydroxylapatite (HA) and demineralized rat femur particles (DP) and bone tissue reaction to these materials were histologically evaluated.These composite materials were implanted subperiosteally over the parietal bone and the man dible with the framework of milipore-filter in 12 week-old Wistar rats. Histological examination revealed that the implantation of PLA-HA composite resulted in no bone formation, whereas DP composite induced marked new bone formation on the surface of the host bone.These,results suggest that DP composite has a promising candidate as a new augmentation material and a new system using DP composite with milipore-filter framework may be a predictable method for bone augmentation.