A study on the development of new bone a angmentation material composed of biodegradable poly-lactic acid and hydroxylapatite

为了开发一种新型骨增强材料，以生物可吸收聚聚酸（PLA）、羟基磷灰石（HA）和脱矿大鼠股骨颗粒（DP）为原料制备了复合材料，并对其骨组织反应进行了组织学评价。将这些复合材料在12周龄Wistar大鼠骨膜下植入顶骨，并以微孔滤过器为框架植入人食。组织学检查显示PLA-HA复合材料的植入未导致骨形成，而DP复合材料在宿主骨表面诱导了明显的新骨形成。这些结果表明，DP复合材料是一种很有前途的新型骨增强材料，使用DP复合材料和微孔过滤器框架的新系统可能是一种可预测的骨增强方法。

In order to develop a new bone augmentation material, some composite materials were fabricated from bioabsorbable polytactic acid (PLA), hydroxylapatite (HA) and demineralized rat femur particles (DP) and bone tissue reaction to these materials were histologically evaluated.These composite materials were implanted subperiosteally over the parietal bone and the man dible with the framework of milipore-filter in 12 week-old Wistar rats. Histological examination revealed that the implantation of PLA-HA composite resulted in no bone formation, whereas DP composite induced marked new bone formation on the surface of the host bone.These,results suggest that DP composite has a promising candidate as a new augmentation material and a new system using DP composite with milipore-filter framework may be a predictable method for bone augmentation.