A study on the development of new bone a angmentation material composed of biodegradable poly-lactic acid and hydroxylapatite

可生物降解聚乳酸与羟基磷灰石新型骨强化材料的研制

• 批准号: 62870078
• 负责人: TSURU Hiromichi
• 金额: $ 5.7万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62870078/
• 关键词: Polylactic acidapatite composite; Bioabsorbable polymer; Augmentation; Demineralized bone; Bone induction; ポリマー・アパタイト複合体; 骨造成材料; インプラント

In order to develop a new bone augmentation material, some composite materials were fabricated from bioabsorbable polytactic acid (PLA), hydroxylapatite (HA) and demineralized rat femur particles (DP) and bone tissue reaction to these materials were histologically evaluated.These composite materials were implanted subperiosteally over the parietal bone and the man dible with the framework of milipore-filter in 12 week-old Wistar rats. Histological examination revealed that the implantation of PLA-HA composite resulted in no bone formation, whereas DP composite induced marked new bone formation on the surface of the host bone.These,results suggest that DP composite has a promising candidate as a new augmentation material and a new system using DP composite with milipore-filter framework may be a predictable method for bone augmentation.

为了开发一种新的骨增量材料，将可吸收的聚乳酸（PLA）、羟基磷灰石（HA）和脱钙大鼠股骨颗粒（DP）制成复合材料，并将其植入12周龄Wistar大鼠的顶骨和下颌骨骨膜下，观察其骨组织反应。组织学观察显示，PLA-HA复合材料植入后无骨形成，DP复合材料植入后可在宿主骨表面诱导明显的新骨形成，提示DP复合材料是一种很有前途的新型骨增强材料，DP复合材料与微孔过滤器支架的复合系统可能是一种可预测的骨增强方法。