Development of bioglass coated titanium implant

生物玻璃涂层钛植入物的开发

• 批准号: 59870062
• 负责人: TSURU Hiromichi
• 金额: $ 5.63万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1984
• 资助国家: 日本
• 起止时间: 1984 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59870062/
• 关键词: implant; ceramic; bioglass; 病理組織

To examine a possibility of clinical use of the hybrid material (Ti6Al4V with Bioglass coating) for endosseous dental implant, two experiments were performed using Japanese monkeys.(1) Initial bone healing was compared histologically between two implants. There were inserted into edentulous areas of both sides of the mandible, one by tapping and the other by non-tapping methods. Both implants were covered with a muco-periosteal flap of full thickness and allowed to heal for 3 months. All bioglass-coated implants, which ever the insertion method was, showed good healing with direct bone apposition, where as the controls without bioglass coating revealed various amonts of fibrousconnective tissue between bone and implant.(2) Bioglass implants were inserted into the mandible by non-tapping method and loaded with functional stress by means of the superstructure. After 3, 6 and 9 months of function, histological specimens were prepare. Directory bone-implant interface was obviously achived in most regions along the outline of screw-saped implants.

为了探讨混杂材料(Ti6Al4V生物玻璃涂层)在临床上应用于骨内种植体的可能性，用日本猴进行了两个实验：(1)比较了两种种植体的初始骨愈合情况。分别采用攻丝和非攻牙两种方法植入双侧下颌骨无牙区。两种种植体均覆盖全厚粘膜骨膜瓣，愈合时间为3个月。无论采用何种植入方式，生物玻璃涂层种植体均表现出良好的骨性愈合，直接与骨结合，而未涂覆生物玻璃涂层的对照组种植体骨与种植体之间可见大量纤维结缔组织。(2)将生物玻璃种植体以非攻丝方式植入下颌骨，并通过上层建筑施加功能应力。术后3个月、6个月、9个月取材。种植体-骨界面沿螺纹式种植体轮廓的大部分区域均有明显的方向性。

项目成果

里見圭一,山田哲之,福岡賢二,前田希,石田栄作,高鳥忠彦,赤川安正,津留宏道: 日本補綴歯科学会雑誌. 31. (1987)

Keiichi Satomi、Tetsuyuki Yamada、Kenji Fukuoka、Nozomi Maeda、Eisaku Ishida、Tadahiko Takatori、Yasumasa Akakawa、Hiromichi Tsuru：日本口腔修复学会杂志 31。（1987）。

Keiichi Satomi, Yasumasa Akagawa, Hiromasa Nikai, Hiromichi Tsuru: "Tissue reaction to endosseous hydroxyapatite coated titanium alloy implants. <II> . Reaction of bone tissue" The Journal of the Japan Prosthodontic Society. 19. (1987)

Keiichi Satomi、Yasumasa Akakawa、Hiromasa Nikai、Hiromichi Tsuru：“骨内羟基磷灰石涂层钛合金植入物的组织反应。<II>。骨组织的反应”日本修复医学会杂志。

里見圭一,赤川安正,二階宏昌,津留宏道: 広島大学歯学雑誌. 19. (1987)

Keiichi Satomi、Yasumasa Akakawa、Hiromasa Nikai、Hiromichi Tsuru：广岛大学牙科杂志 19。（1987 年）

Keiichi Satomi, Takahiko Ikeda, Yasunori Kaide, Hidenobu Tomita, Kenji Fukuoka, Naoto Ukita, Kouji Nagakane, Nozomu Maeda, Yuuji Sato, Masaki Hashimoto, Yasumasa Akagawa, Hiromichi Tsuru: "Experimental study on tissue structure surrounding submergible imp

Keiichi Satomi、Takahiko Ikeda、Yasunori Kaide、Hienobu Tomita、Kenji Fukuoka、Naoto Ukita、Kouji Nagakane、Nozomu Maeda、Yuuji Sato、Masaki Hashimoto、Yasumasa Akakawa、Hiromichi Tsuru：《关于潜水小恶魔周围组织结构的实验研究》

里見圭一,池田隆彦,貝出泰範,富田秀伸,福岡賢二,浮田直人,永金幸治,前田希,佐藤裕二,橋本正毅,赤川安正,津留宏道: 日本歯科インプラント学会誌. 7. 150 (1986)

Keiichi Satomi、Takahiko Ikeda、Yasunori Kaide、Hienobu Tomita、Kenji Fukuoka、Naoto Ukita、Koji Nagakin、Nozomi Maeda、Yuji Sato、Masatake Hashimoto、Yasumasa Akakawa、Hiromichi Tsuru：日本牙科种植学会杂志（1986 年）。 ）