Studies on epidemiology and transmission mechanisms of lymphocytic choriomeningitis virus in Japan.

最近，我们报道了在日本两个国际口岸出现淋巴细胞性脉络丛脑膜炎病毒（LCMV）的抗体和分离。到目前为止，在日本其他任何地方检测抗体或病毒的尝试都没有成功。我们利用核糖体DNA和线粒体DNA的遗传分析来检测小家鼠的亚种。包括日本lcmv阳性港口在内的一些地区的肌肉。结果表明，镰状芽孢杆菌被认为是病毒入侵日本的载体宿主。目前未见在褐毛鼠栖息地检测到LCMV的报道。对包括中国在内的6个国家的调查显示，卡斯塔尼乌斯虫中存在LCMV。此外，在中国北方甘苏氏m.m.s ansuensis栖息地捕获的小鼠中发现了LCMV抗体。LCMV被认为是通过从大坝到其后代的垂直传播来维持的。我们分析了在大阪港捕获的小鼠的母系谱系。病毒的水平传播对维持该病毒在野生家鼠种群中的传播具有重要作用。

Recently, we reported occurrence of antibodies and isolation of lymphocytic choriomeningitis virus (LCMV) in two international ports in Japan. Attempts to detect the antibody or the virus in any other place in Japan have not succeeded until now. We utilized genetic analysis of ribosomal DNA and mitochondrial DNA to detect subspecies of Mus.musculus in some areas including LCMV-positive ports in Japan. As the results, M.m.castaneus was assumed to be the carrier reservoir of the virus invading to Japan. There is no report detecting LCMV in the habitat area of M.m.castaneus. The survey of 6 countries including China revealed LCMV existed in M.m.castaneus. In addition, the antibodies against LCMV were revealed in the mice captured in the northern part of China where was the habitat of M.m.gansuensis. LCMV is thought to be maintained by vertical transmission from dams to their offsprings. We analyzed matrilineal linage of mice captured in Osaka Port. Horizontal transmission of the virus has an important role to maintain the virus in the population of the wild house mouse.