Clinicopathologic and biologic study of the neoplasms arising from the T-cell area of the lymph node.

在本研究中，我们研究了肿瘤从T细胞区的淋巴结。根据更新的基尔（Suchi）分类法对外周T细胞淋巴瘤（PTCL）进行分类。总结了基于淋巴结的低度PTCL（AILD型、T区型和淋巴上皮样型）的临床病理学、表型和基因型结果（Cancer 1991 ; 67：2565）。这些肿瘤中的肿瘤细胞（CD 4+，Ki 67+）的比例被证明与克隆TCR β重排具有相对良好的相关性（Cancer 1993 ; 72：1762，Acta Pathol Jpn 1993 ; 43：396）。在这个过程中（癌症1993 ; 71：249）。另外10例病例的累积表明它们构成了一个被认为是高度恶性淋巴瘤的独特亚组，尽管有些可能是自然杀伤（NK）细胞谱系，指状细胞肉瘤是一种非常罕见的肿瘤，起源于淋巴结的副皮质区（Cancer 1988 ; 61：562）。最近，我们描述了四例这种肿瘤的组织学和免疫表型特征（Pathol Int 1994 ;在印刷中），我们将研究癌基因和抑癌基因在这些肿瘤中的参与。

In the present study, we investigated the tumor arsing from the T-cell area of the lymph node. Peripheral T-cell lymphoma (PTCL) was classified according to the updated Kiel (Suchi) classification. The clinicopathologic, phenotypic and genotypic findings of node-based, low-grade, PTCL (AILD type, T-zone type, and lymphoepithelioid type) were summarized (Cancer 1991 ; 67 : 2565). The proportion of the neoplastic cells (CD4+, Ki67+) in these tumors was demonstrated to have a relatively good correlation with the clonal TCRbeta rearrangement (Cancer 1993 ; 72 : 1762, Acta Pathol Jpn 1993 ; 43 : 396). In the process of the (Cancer 1993 ; 71 : 249). An accumulation of the additional 10 cases of this tumor suggested them to constitue a unique subgroup regarded as high-grade lymphoma, although some might be of natural killer (NK) cell lineage.Interdigitating cell sarcoma was an extremely rare tumor arising from the paracortical area in the lymph node (Cancer 1988 ; 61 : 562). Recently, we described the histologic and immunophenotypic features of four cases of this tumor (Pathol Int 1994 ; in press).We are going to examine the participation of oncogene and antioncogene in those tumors.