A study of Hemodynamic changes and Regroral Blood Flows, under Hemodilution with Hypotoni

研究了异氟醚和帕库林麻醉单细胞犬的血液动力学变化、冠状动脉和心肌血流对急性血液稀释和控制性低血压的反应。取全血，按取血量的1.5倍滴注6%羟乙基淀粉，以20ml/lay的速度稀释至血细胞比容20-22%。随后，在平均动脉压为70mmHg的情况下，通过注射SNP使血压降低90分钟。得到了以下结果。(1) SNP降压时PVV_2、SVV_2无明显变化。(2)低血压时心脏指数明显升高。(3)心率无明显变化。(4)冠状动脉和心肌血液：出现低血压时，血流速度明显减慢。(5)未观察到SNP引起的氰化物中毒迹象。从这些结果中。该方法安全、实用。

Hemodynamic changes, coronary and myocardial blood flow response to acute hemodilution and controlled hypotension were stuotied in monyrcel dogs anesthetized isoflurane and paralized Pamcurorim. Hemodilution to hematocrit of 20-22% was produced by 20ml/lay by removal of whole blood and infusion of 6% Hydroxyethyl Starch in 1.5 times the volume of blood removed. Subsequently hypotension was produece for 90 minutes by intrracenons infusion of SNP,at mean arterial pressure of 70mmHg. The following results were oftained.(1)PVV_2, SVV_2 were unchanged during hypotension by SNP.(2)Cardiac Fndex alvowed a significant increase during hypotension.(3)Heurt rate did not show significant change.(4)Coronary and myocardial blood How slorowed a significant increuse arring hypotension(5)Sign of cyanide coxicity by SNP were not observed. From these results. This method is safety and useful clinicaly.