Prescription for health promotion with combined use of health-, fitness-, and lifestyle markers

许多流行病学研究表明，锻炼对心血管疾病和癌症具有保护作用。然而，运动处方还没有确定。以爱知县保健院综合健康体检和体能检查(第一研究)和体育锻炼计划(第二研究)的受试者为研究对象，在没有昂贵机器和侵入性的情况下(第一研究)，试图估计“无氧阈值(AT)”作为最佳运动强度，并分析计划体育锻炼对冠状动脉危险因素的影响(第二研究)。我们对与健康和健身相关的标记物进行了单因素和多变量分析。在第一个研究中，我们用标记物间的相关性分析确定了最佳拟合模型，2)用最大摄氧量(VO&lt；2max&gt；)和AT作为因变量，用其他生物标记物代替自变量，进行了多元回归分析，3)建立了男女性别的回归方程。预测与实测值之间的相关系数为0.53~0.78。在第二项研究中，我们实施了为期6个月的AT级运动计划，结果表明：1)体脂、收缩压、舒张压、总胆固醇、甘油三酯显著降低，AT、VO；2max&gt；；2)总胆固醇和空腹血糖在轻度衰退组比重度衰退组改善得更好；3)健康指标的改善与健身评分员的改善有关。

Many epidemiological studies showed that exercise was protective against cardiovascular diseases and cancers. Prescription of exercise, however, has not established yet. We tried to estimate "anaerobic threshold (AT) " as an optimal exercise strength without costly machines nor invasion (first study), and analyzed the effects of the programd physical exercise on coronary risk factors (second study).The subjects were participants of the comprehensive health check and fitness check (first study), and those of the physical exercise program (second study) at Aichi Prefectural Center of Health Care. We carried out single-and multi-variate analyzes for health-and fitness-related markers.In the first study, 1) we determined the best-fit model using an inter-marker correlation analysis, 2) performed a multiple regression procedure substituting maximum oxygen uptake (VO_<2max>) and AT for dependent variables and the other biological markers for independent variables, 3) made up a regression equation for each sex. The correlation coefficients between the predicted and the measured values were 0.53-0.78.In the second study, we carried out a 6-month AT-leveled exercise program, and elucidated that 1) body fat, systolic and diastolic blood pressure, total cholesterol, and triglycerides were significantly decreased, and AT and VO_<2max> were significantly increased ; 2) total cholesterol and fasting plasma glucose were improved among the mildly deteriorated subjects better than the severely deteriorated ones ; 3) improvement of health markers were associated with that of fitness markers.In this study, we developed a new feasible exercise prescription and showed its usefulness.