Growth prediction of jaws by using serum and urinary levels of bone metabolic markers

研究了青春期晚期颌骨(III类)颅面结构的生长相关变化及其与血和尿中生长激素(GH)、胰岛素样生长因子I(IGF-I)、骨钙素(OC)、前胶原-III-肽(PIIIP)、吡啶(PYR)和脱氧吡啶(DPYR)水平的关系。结果如下：1.在青春期晚期，III类和I类受试者的血、尿生长因子浓度和头面部测量值的平均增量无显著差异。血清生长因子水平与颅面测量之间无相关性。下颌骨大小的平均增量与OC、PIIIP、PYR和DPYR水平显著相关，提示中度下颌前突患者和正常咬合患者的生长相关因子水平相似。此外，OC、PIIIP、PYR和DPYR是反映青春期晚期颅面发育残余量的敏感指标。

Growth-related changes in skeletal prognathic (Class III) craniofacial structure in late adolescence were investigated in relation to serum and urinary levels of growth factors including growth hormone (GH), insulin-like growth factor I (IGF-I), osteocalcin (OC), procollagen-III-peptide (PIIIP), pyridinoline (PYR) and Deoxypyridinoline (Dpyr).The subjects were evaluated on the basis of serial lateral cephalometric X-rays, hand bone X-rays, and serum or urinary levels of growth factors.The results were as follows :1. There was no significant difference in serum and urinary concentrations of growth factors or mean increments of craniofacial measurements between Class III and Class I subjects in late adolescence.2. There was no correlation between serum levels of growth factors and craniofacial measurements.3. The mean increments of mandibular size correlated strongly with levels of OC,PIIIP,Pyr and Dpyr.These results suggested that the levels of growth related factors were similar in patients with moderate mandibular prognathism and persons with normal occlusion. Furthermore, it was suggested that OC,PIIIP,Pyr and Dpyr were sensitive markers of the remaining amount of craniofacial growth in late adolescence.