Comparative psychological studies of spatial and temporal integration in hippocampus

该项目的目的是对海马体功能进行比较研究，我们获得了以下结果。鱼类研究：我们为金鱼开发了Morris-迷宫模拟任务，并明确了背内侧端脑的病变选择性地损害了空间学习，而不是标志性学习。鸟类研究：我们使用了鸽子、斑马雀和灌木鸟。我们比较了射频、鹅膏油酸和抽吸法对鸽子海马区损伤的效果，发现每种方法都会导致严重的空间学习障碍。另一方面，海马区的损伤并没有导致WGTA样任务的严重缺陷。在WGTA样任务中，基底节损害导致表现迟缓。斑马雀的病变研究与鸽子的研究结果一致，尽管斑马雀是在大型鸟类养殖场接受训练的。灌木鸟通过观察其他鸟类的缓存来获得空间信息，我们没有对鸟儿进行任何损伤研究。罗杰特研究：我们训练大鼠执行类似鸽子重复…的任务更多的收购程序。大鼠的海马区损伤导致了与鸽子实验相似的缺陷。我们检查了“空间认知”任务中的几个环境和行为变量，并比较了海马区损伤与穹隆、颞叶皮质和杏仁核损伤的影响。我们还研究了MNDA受体在空间认知中的作用。对于时间辨别，我们测量了在时间辨别过程中的海马theta波，并进行了从内侧前额叶取样的微透析。C57小鼠的脑缺血也造成了Morris迷宫的缺陷，但不影响物体识别任务。人类研究：我们建立了Morris-S迷宫模拟手指迷宫，并比较了这项任务在海马区损伤前后的表现。我们在右侧海马区损毁后观察到迟缓，但在右侧海马区损毁后未观察到迟缓。对海马区受损的阿尔茨海默病和柯萨科夫病患者进行的神经心理学检查显示，空间和时间信息的整合存在缺陷。摘要：我们比较了几个不同物种的空间认知，发现海马体通过从鱼类到人类的不同物种在空间认知中发挥作用。对于时空信息整合的对比研究，我们虽然获得了大量有趣的数据，但并没有完成研究。较少

The purpose of the project is comparative study of hippocampal function and we obtained the results below.Fish study : We developed Morris-maze analog task for gold fish and clarified lesion in the dorsomedial telencephalon selectively damaged spatial learning but not landmark learning.Avian study : We used pigeon, zebra finches and scrub jays. We compared effect of hipocampal lesions by radiofrequency, ibotenic acid and aspiration in pigeons and found every method resulted in severe deficit in spatial learning. On the hand, the hippocampal lesions did not cause severe deficits in WGTA like task. The basal ganglion lesions retarded performance in the WGTA-like task. Lesions studies with the zebra finches agreed to those with pigeons even though the finches were trained in the large aviary. The scrub jays obtained spatial information by observing caching of the other birds, we did not done any lesion study with the jay.Rodent study: We trained rats on a task similar to pigeon's repeated … More acquisition procedure. The hippocampal lesions in rats resulted in a similar deficits to pigeon experiment. We examined several environmental and behavioral variables in "spatial cognition" tasks and compared effects of hippocampal lesions with those of finbria, temporal cortex and amygdale. We examined role of MNDA receptor in spatial cognition also. For temporal discrimination, we measured hippocampal theta- wave during temporal discrimination and also run microdialysis sampled from medial prefrontalis. Ischemia in C57 mice also caused deficits in Morris-maze but not in object recognition task.Human study : We developed Morris-s-maze analog finger-maze and compared performance in this task before and after the hippocampal lesions. We observed retardation after the right hippocampal lesions but not after the right hippocampal lesions. Neuropsychological examination of Alzheimer and Korsakov patients who had damages in the hippocampi showed deficits in integration of spatial and temporal information.Summary : We compared spatial cognition with several different species and found that the hippocampus has a role in spatial cognition through these different species from fish to human. For comparative study of integration of spatial and temporal information, we did not complete the research although we obtained a lot of interesting data. Less