The elucidation and preventive medical risk evaluation of the effects on the next generation in human exposed to endocrine disrupting chemicals.

1.对514名孕妇进行了前瞻性队列研究，以调查二恶英、多氯联苯和全氟辛烷磺酸/全氟辛酸等内分泌干扰物对下一代的影响。本研究对每位母亲在妊娠期、产后18个月和42个月的日常饮食、生活方式和职业进行了调查，并测量了母亲血液中环境化学物质浓度与其对婴儿健康影响之间的关系.母亲血中单邻位PCBs-TEQ浓度与新生儿TSH水平呈负相关，母亲血中总PCDD/PCDFs-TEQ浓度与新生儿FT 4水平呈正相关，推测PCBs和二恶英对新生儿甲状腺功能无抑制作用.我们已经证实母体血液中的多氯二苯并呋喃对胎儿发育有不利影响，因为母体血液中的多氯二苯并呋喃总浓度、出生体重和SGA之间存在负相关。我们的结论是，在背景水平的二恶英在子宫中的暴露可能会影响胎儿的免疫系统，因为在母体血液中的33 '4' 4 '-TCB和在脐带血中的IgE水平之间发现的正相关性。我们发现，母亲血液中的多氯联苯和二恶英浓度会对六个月大的儿童的神经系统产生不良影响。这被认为对身体发育有影响。在PCDDS、PCDFs和Coplanar PCBs中，只有Coplanar PCBs在母体血液中的浓度与母体头发中的汞浓度呈正相关。我们的研究表明，吸烟的遗传易感性可能会对胎儿的生长产生不利影响。在AhR野生基因型、CYP 1A 1变异基因型或GSTM 1无效基因型吸烟者所生婴儿中，出生体重和出生身长显著降低。

1. The prospective cohort study involving 514 pregnant women was carried out to investigate the effects of endocrine disruptors such as dioxins, PCBs and PFOS/PFOA on next generations. We have conducted a survey on each mother based on their daily diet, life styles, and occupation at their gestational period, 18 and 42 months after giving birth, and measured the associations between maternal blood concentrations of environmental chemicals and their effect on infant health.2. Since we found a negative relation between maternal blood concentration of Mono-ortho PCBs-TEQ and newborn's TSH Ievel,and a positive one between maternal blood concentration of Total PCDD/PCDFs-TEQ and newborn's FT4 level, it was supposed that PCBs and dioxin have no restraint on the infant's thyroid function.3. We have approved that PCDFs in maternal bloods have adverse effects on fetal development because of the negative associations between total PCDFs concentration in maternal bloods, birth weight and SGA.4. We conclude that exposure of dioxin in the uterus at the background-level may effect the fetal immuno-system because of the positive association found between the 33'4'4'-TCB in maternal bloods and the IgE level in umbilical bloods.5. We found that PCBs and dioxin concentrations in maternal bloods cause adverse effects on the neurological system of six-month-old children. This is seen to have effect on the physical development.6. Among PCDDS, PCDFs and Coplanar PCBs, only the concentration of Coplanar PCBs in maternal bloods had a positive correlation with mercury concentration in maternal hair. Our study suggested that genetic susceptibility to tobacco smoke may adversely affect fetal growth. Among infants born to smokers with the AhR wild genotype, CYP1A1 variant genotype, or the GSTM1 null genotype, birth weight and birth length were significantly reduced.