Molecular mechanism involved in the association of periodontal disease with pathology of metabolic syndrome

本研究的目的是研究牙周病与代谢综合征的各种组成部分之间的关系。在流行病学研究中，高血压和牙周炎作为危险指标与大血管疾病显著相关。与没有牙周炎的受试者相比，患有牙周炎的受试者的炎症生物标志物（包括ICAM）水平显著增加。在载脂蛋白e缺乏的小鼠中，高胆固醇饮食和感染牙龈卟啉单胞菌会加速炎症细胞因子和动脉粥样硬化。此外，一系列体外感染研究表明，牙周病原体引起牙龈上皮细胞的细胞周期失调。

The purpose of this investigation was to examine the association of periodontal disease and various components of metabolic syndrome. In epidemiological studies, high blood pressure and periodontitis were significantly associated with macrovascular disease(s) as risk indicators. Levels of the inflammatory biomarkers including ICAM in the subjects with periodontitis increased meaningfully in comparison with the subjects without periodontitis. In apolipoprotein E-deficient mice, high-cholesterol diet and infection with Porphyromonas gingivalis accelerated inflammatory cytokines and atherosclerosis. Furthermore, a series of in vitro infection studies revealed that a periodontal pathogen caused cell cycle dysregulation in gingival epithelial cells.