Biomechanical regulation of cell shape, proliferation and cell death
Biomechanical regulation of cell shape, proliferation and cell death
批准号:
21870040
负责人:
HAYASHI Takashi
金额:
$1.76万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
以果蝇为模型系统,研究了生物力学在细胞形态控制、细胞增殖和细胞死亡中的作用。通过研究Rho、Rac或非肌肉肌球蛋白在体内的作用,表明细胞的形状受控于细胞骨架产生的表面张力。一个研究生物力学对细胞增殖或死亡作用的实验系统也已经建立起来。
英文摘要
The roles of biomechanics on cell shape control, proliferation and cell death were studied using Drosophila melanogaster as the model system. It has been shown that the shape of cells is under the control of surface tension, which is produced by cytoskeletons, by studying the effects of manipulating the function of Rho, Rac or non-muscle Myosin in vivo. An experimental system for studying the roles of biomechanics on proliferation or cell death has also been established.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
ショウジョウバエ視細胞の形態決定過程を支配する分子メカニズムとその数理モデル
果蝇感光细胞形态决定过程的分子机制及其数学模型
DOI:
--
发表时间:
2009
期刊:
生物物理 Vol.49、No.6
影响因子:
--
作者:
[Motoki Takaku, Takashi Kainuma, Takako Ishida-Takaku, et al., 林貴史]
通讯作者:
林貴史
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DOI:
--
发表时间:
期刊:
影响因子:
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作者:
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通讯作者:
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