Cardiac Impedance Measurement for Improved Hemodynamic Monitoring - CIMI

在这个项目中，我们建议建立一个集成在左心室辅助装置（LVAD）上的心内生物阻抗测量来监测心脏的血容量变化和容量流量。因此，我们希望将重点放在VAD支持期间发生的血流状况和晚期心力衰竭心脏的病理变化上。我们希望研究是否以及在多大程度上心内阻抗监测的准确性可以通过改进的有限元建模近似。我们推测，在这种治疗环境中，改进的心内阻抗监测可以作为心室容积的适当替代参数。此外，我们推测监测左心室容量和主动脉流量将允许优化VAD操作参数设置，并可能提高患者的生活质量。最后，可以确定不良事件，并适应各种负荷条件，为患者提供个性化治疗。

In this project, we propose to establish intracardial bioimpedance measurements integrated on a left ventricular assist device (LVAD) to monitor the blood volume changes and the volumetric flows in the heart. Therefore, we want to focus on flow conditions occurring during the support with a VAD and pathological changes of the heart suffering from advanced heart failure. We wish to investigate if and how much the accuracy of intracardial impedance monitoring can be approximated by improved finites element modelling. We speculate that improved intracardial impedance monitoring can be a proper surrogate parameter for ventricular volume in this therapeutic setting. Furthermore, we speculate that monitoring of left ventricular volume and aortic flow will allow optimization of VAD operating parameter settings and may improve the quality of life of patients. Finally, adverse events can be determined and the adaptation to various loading conditions enables an individual treatment for the patient.