Systemic Inflammatory Response Indication Observer (SIRIO)

SIRIO项目（全身性炎症反应指示观察）的目的是开发一种用于早期发现早产儿败血症的混合摄像机监测系统。SIRIO将基于摄像机的生命参数监测系统光电体积脉搏成像和红外成像融合为基于摄像机的混合成像技术，用于新生儿生命状态检测。这两种方法都是非接触获取重要参数的新方法。因此，它们可以在现有基础设施之外运行。另一个优点是没有与病人直接接触，因此早产儿的皮肤不会受到伤害。一般来说，患者不会受到任何额外的压力，也没有感染的风险（由测量技术引起的）。这种混合测量技术允许非接触检测生命体征，包括：1)皮肤血液循环，2)心脏和呼吸频率及其变异性，3)皮肤灌注（中央和周围），4)皮肤颜色，5)身体活动。根据这些测量的参数，将自动识别第一个脓毒症适应症。这些败血症特征将融合到评分参数中。该评分参数将来源于儿科早期预警评分（PEWS），该评分已在临床常规中建立。如果首次出现脓毒症症状，则会触发警报，以便根据标准治疗指南启动下一个手动步骤，而不会浪费时间：确认诊断，例如通过检查毛细血管化时间，测定血培养和后续治疗。该项目设想了混合监测概念的实施和信号处理程序的开发，为参加的临床工作人员提供实时决策支持系统-不引人注目，并增加了新生儿站的现有基础设施。为了这个项目，当地伦理委员会批准了一项20名早产儿的临床人体研究。在临床前试验的基础上，本研究将对该系统的可行性进行验证。

The aim of the SIRIO project (Systemic Inflammatory Response Indication Observer) is the development of a hybrid camera monitoring system for an early detection of sepsis in premature infants. SIRIO fuses the camera-based vitalparamater monitoring systems Photoplethysmography Imaging and Infrared Imaging into a camera-based Hybrid Imaging technology for the vital state detection in neonates. Both methods are novel approaches to obtain vital parameters contactless. Hence, they can operate in addition to the existing infrastructure. A further advantage is that there is no direct contact with the patient so that the premature infant skin is not harmed. In general, the patient is not subjected to any additional stress and there is no risk of infection (caused by the measurement technique). This hybrid measuring technique allows the contactless detection of vital signs, including: 1) cutaneous blood circulation, 2) heart and respiratory rate as well as their variability, 3) the skin perfusion (central and peripheral), 4) skin coloring, and 5) physical activity.From these measured parameters, first septic indications will be automatically recognized. These septic features will be fused into a scoring parameter. This scoring parameter will be derived from the Pediatric Early Warning Score (PEWS), which is already established in the clinical routine. In case of first septic signs, an alarm is triggered, so that the next manual steps can be initiated according to the standard treatment guidelines without time loss: confirmation of the diagnosis, e.g. by checking the capillarization time, determination of blood culture and subsequent therapy.The project envisages the implementation of the hybrid monitoring concept and the development of signal processing routines, which provide a real-time decision support system for the attending clinical staff - unobtrusively and additively to the existing infrastructure at the neonatology station.For this project, the local Ethics Committee authorized a clinical human study with 20 preterm infants. Based on preclinical tests, the feasibility of this system will be proved within this study.