Systemic Inflammatory Response Indication Observer (SIRIO)

全身炎症反应指示观察仪（SIRIO）

• 批准号: 389432072
• 负责人: Professor Dr.-Ing. Steffen Leonhardt
• 金额: --
• 依托单位: Lehrstuhl für Medizinische Informationstechnik (MedIT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/389432072?language=en
• 关键词: Systemic; Inflammatory; Response; Indication; Observer

The aim of the SIRIO project (Systemic Inflammatory Response Indication Observer) is the development of a hybrid camera monitoring system for an early detection of sepsis in premature infants. SIRIO fuses the camera-based vitalparamater monitoring systems Photoplethysmography Imaging and Infrared Imaging into a camera-based Hybrid Imaging technology for the vital state detection in neonates. Both methods are novel approaches to obtain vital parameters contactless. Hence, they can operate in addition to the existing infrastructure. A further advantage is that there is no direct contact with the patient so that the premature infant skin is not harmed. In general, the patient is not subjected to any additional stress and there is no risk of infection (caused by the measurement technique). This hybrid measuring technique allows the contactless detection of vital signs, including: 1) cutaneous blood circulation, 2) heart and respiratory rate as well as their variability, 3) the skin perfusion (central and peripheral), 4) skin coloring, and 5) physical activity.From these measured parameters, first septic indications will be automatically recognized. These septic features will be fused into a scoring parameter. This scoring parameter will be derived from the Pediatric Early Warning Score (PEWS), which is already established in the clinical routine. In case of first septic signs, an alarm is triggered, so that the next manual steps can be initiated according to the standard treatment guidelines without time loss: confirmation of the diagnosis, e.g. by checking the capillarization time, determination of blood culture and subsequent therapy.The project envisages the implementation of the hybrid monitoring concept and the development of signal processing routines, which provide a real-time decision support system for the attending clinical staff - unobtrusively and additively to the existing infrastructure at the neonatology station.For this project, the local Ethics Committee authorized a clinical human study with 20 preterm infants. Based on preclinical tests, the feasibility of this system will be proved within this study.

SIRIO项目（全身炎症反应指标观察者）的目的是开发一种混合摄像机监测系统，用于早产儿败血症的早期检测。SIRIO将基于摄像头的生命参数监测系统光电体积描记成像和红外成像融合到基于摄像头的混合成像技术中，用于新生儿的生命状态检测。这两种方法都是非接触式获取生命参数的新方法。因此，它们可以在现有基础设施的基础上运行。另一个优点是不与患者直接接触，因此早产儿皮肤不会受到伤害。一般来说，患者不会受到任何额外的压力，也没有感染的风险（由测量技术引起）。这种混合测量技术允许非接触式检测生命体征，包括：1）皮肤血液循环，2）心率和呼吸频率及其变异性，3）皮肤灌注（中央和外周），4）皮肤颜色，和5）身体活动。从这些测量参数中，将自动识别第一个脓毒症指示。这些脓毒症特征将被融合到评分参数中。该评分参数将来自儿科早期预警评分（PEWS），该评分已在临床常规中确立。如果出现第一个脓毒症迹象，则会触发警报，以便根据标准治疗指南启动下一个手动步骤，而不会浪费时间：通过检查毛细血管形成时间、确定血培养和随后的治疗来确认诊断。该项目设想实施混合监测概念和开发信号处理程序，为临床工作人员提供实时决策支持系统--不引人注意地添加到儿科站的现有基础设施中。对于该项目，当地伦理委员会授权对20名早产儿进行临床人体研究。基于临床前试验，本研究将证明该系统的可行性。