Systemic Inflammatory Response Indication Observer (SIRIO)

全身炎症反应指示观察仪（SIRIO）

• 批准号: 389432072
• 负责人: Professor Dr.-Ing. Steffen Leonhardt
• 金额: --
• 依托单位: Lehrstuhl für Medizinische Informationstechnik (MedIT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/389432072?language=en
• 关键词: Systemic; Inflammatory; Response; Indication; Observer

The aim of the SIRIO project (Systemic Inflammatory Response Indication Observer) is the development of a hybrid camera monitoring system for an early detection of sepsis in premature infants. SIRIO fuses the camera-based vitalparamater monitoring systems Photoplethysmography Imaging and Infrared Imaging into a camera-based Hybrid Imaging technology for the vital state detection in neonates. Both methods are novel approaches to obtain vital parameters contactless. Hence, they can operate in addition to the existing infrastructure. A further advantage is that there is no direct contact with the patient so that the premature infant skin is not harmed. In general, the patient is not subjected to any additional stress and there is no risk of infection (caused by the measurement technique). This hybrid measuring technique allows the contactless detection of vital signs, including: 1) cutaneous blood circulation, 2) heart and respiratory rate as well as their variability, 3) the skin perfusion (central and peripheral), 4) skin coloring, and 5) physical activity.From these measured parameters, first septic indications will be automatically recognized. These septic features will be fused into a scoring parameter. This scoring parameter will be derived from the Pediatric Early Warning Score (PEWS), which is already established in the clinical routine. In case of first septic signs, an alarm is triggered, so that the next manual steps can be initiated according to the standard treatment guidelines without time loss: confirmation of the diagnosis, e.g. by checking the capillarization time, determination of blood culture and subsequent therapy.The project envisages the implementation of the hybrid monitoring concept and the development of signal processing routines, which provide a real-time decision support system for the attending clinical staff - unobtrusively and additively to the existing infrastructure at the neonatology station.For this project, the local Ethics Committee authorized a clinical human study with 20 preterm infants. Based on preclinical tests, the feasibility of this system will be proved within this study.

Sirio项目（系统性炎症反应指示观察者）的目的是开发混合摄像头监测系统，以早日败血症的早期发现。 Sirio将基于摄像机的VitalParamater监测系统融合在一起，并将红外化成像和红外成像融合到基于摄像机的混合成像技术中，以用于新生儿的重要状态检测。两种方法都是新的方法，无法接触到重要参数。因此，除了现有的基础架构外，它们还可以运行。另一个优点是与患者没有直接接触，因此不会伤害早产的婴儿皮肤。通常，患者没有承受任何额外的压力，也没有感染的风险（由测量技术引起）。这种杂种测量技术允许无接触式的生命体征检测，包括：1）皮肤血液循环，2）心脏和呼吸率以及它们的可变性，3）皮肤灌注（中心和外周），4）肤色和5）体育锻炼。从这些测量参数中，首先是自动认识的这些测量参数。这些化粪池功能将融合为评分参数。该评分参数将源自在临床常规中已经确定的小儿预警评分（PEWS）。如果是第一个化粪池迹象，则会触发警报，以便可以根据标准治疗指南启动下一个手动步骤，而无需时间损失：确认诊断，例如通过检查毛细管时间，血液培养的确定和随后的治疗。该项目设想实施混合监测概念和信号处理惯例的开发，该计划为临床人员提供了实时的决策支持系统，并为新生儿委员会提供了典型的宗教委员会，以无效地对现有的基础设施进行训练。根据临床前测试，将在本研究中证明该系统的可行性。