Epidemiological and molecular investigation on prevalence of antimicrobial resistance in Escherichia coli isolates from pups, diseased dogs, and humans.

在这项研究中，我调查了从狗和人身上分离的大肠杆菌的耐药性流行情况及其相关因素。幼崽源性分离株在每个狗窝中克隆传播，导致不同狗窝之间的抗性流行率不同。此外，耐药流行率与毒力因素和泌尿生殖系统感染犬的系统发育群有关。此外，毒力因子（而非抗菌素耐药性）在犬分离株中比在主人分离株中更为普遍，遗传分析显示狗与其主人之间存在克隆共享。

In this study, I investigated prevalence of antimicrobial resistance and their relative factors in Escherichia coli isolates from dogs and humans. Pup-origin isolates spread clonally in each kennel, resulting in different prevalence of resistance between kennels. In addition, resistance prevalence was associated with virulence factors and phylogenetic groups in dogs with urogenital infections. Furthermore, virulence factors, but not antimicrobial resistance, was more prevalent in canine isolates than in owner isolates, and genetic analysis revealed clone sharing between dogs and their owners.