Genetic polymorphisms of antioxidant enzymes and colorectal carcinogenesis

氧化应激会导致DNA损伤，并可能参与癌症的发生。众所周知，内源性抗氧化酶对氧化应激具有防御作用。为了阐明氧化应激对结直肠癌发生的影响，我们研究了锰超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶功能基因多态性与结直肠腺瘤和肿瘤的关系。在研究中，没有一种基因多态性与结直肠腺瘤风险有可测量的关联。在携带CAT-262C和GT；T等位基因的人群中，发现患结直肠癌的风险显著降低。

Oxidative stress causes DNA damage and may be involved in carcinogenesis. Endogenous antioxidant enzymes are known to be defensive against oxidative stress. To clarify the influence of the oxidative stress on colorectal carcinogenesis, we investigated the relation of functional genetic polymorphisms of manganese superoxide dismutase, catalase, and glutathione peroxidase to colorectal adenomas and cancer. None of the polymorphisms under study showed a measurable association with colorectal adenoma risk. A statistically significant decrease in the risk of colorectal cancer was observed among those with the T allele of CAT-262C>T.