Laser-based multimodal imaging platform for ophthalmology

与许多疾病相关的神经退行性变化和血管功能障碍在眼睛中表现为结构和功能上的自身，在那里它们可以使用现代光子方法进行非侵入性检测。这些基于激光的成像手段包括用于评估角膜形态的共聚焦激光扫描显微镜(CLSM)，特别是基础下神经丛，以及光学相干断层扫描(OCT)。后者允许分析视网膜地形图以及描述视网膜亚结构和视网膜血流动力学(基于染料的血管成像、无染料OCT血管成像)。通过CLSM和OCT，眼科疾病(眼表疾病、视网膜静脉和动脉阻塞、老年性黄斑变性、视神经疾病等)可以这样描述。)以及神经系统(痴呆症、多发性硬化症)、心血管(动脉硬化、高血压)、内分泌/肾脏(糖尿病、盐滞症、肾功能不全)的继发性并发症，但妇科(先兆子痫)疾病也可以以独特的非侵入性方式进行诊断和量化。因此，这些成像模式为早期发现和跟踪多种疾病模式提供了一个跨学科的平台，允许对上述疾病模式进行跨学科研究，并支持我们教师的研究重点。

The neurodegenerative changes and vascular dysfunctions associated with numerous diseases manifest themselves structurally and functionally in the eye, where they can be detected non-invasively using modern photonic methods. These laser-based imaging modalities include confocal laser scanning microscopy (CLSM) for the morphological assessment of cornea, especially the subbasal nerve plexus, and optical coherence tomography (OCT). The latter allows an analysis of the retinal topography and the description of retinal substructures and the dynamics of retinal blood flow (dye-based angiography, dye-free OCT angiography). With CLSM and OCT, ophthalmologic diseases (ocular surface diseases, retinal vein and arterial occlusion, age-related macular degeneration, optic neuropathies, etc.) can be described. ) as well as secondary complications of neurological (dementia, multiple sclerosis), cardiovascular (arteriosclerosis, hypertension), endocrinological/nephrological (diabetes mellitus, salt retention diseases, renal insufficiency), but also gynecological (pre-eclampsia) diseases can be diagnosed and quantified in a unique non-invasive way. Thus, these imaging modalities offer an interdisciplinary platform for early detection and follow-up of numerous disease patterns, allow interdisciplinary studies on the above mentioned disease patterns and support the research priorities of our faculty.